長崎大学病院第一内科 Department of Immunology and Rheumatology, Department of Clinical Neuroscience and Neurology, Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences
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過去の抄読会 (2009年)
「Cortical break でBone edema」
~MRI によってあぶりだされた関節リウマチのはじまり~

• Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. Schett G et al. Arthritis Rheum. 2007 56(4):1118-24.
• High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone. McQueen FM, et al. Ann Rheum Dis 2007 66: 1581-7.
• Schett G. Ann N Y Acad Sci. 2009: 1154; 35-40.
立石洋平先生:Stroke (2009)40:3777-3783, Stroke (2009)40:3784-3788
Predictors of Good Clinical Outcomes, Mortality, and Successful Revascularization in Patients With Acute Ischemic Stroke Undergoing Thrombectomy - MERCI Trials
堀江一郎先生:New Engl J Med (2009) 360:859-873
Cpmparison of Weight-Loss Diets with Different Compositions of Fat, Proteinm and Carbohydrates
川尻真也先生:Arthritis & Rheumatism (2009)60:3180-3189, ARB Online (2009) Oct 14.
“抗TNF 抗体製剤、開始早期発癌リスク上昇か!?”
Cancer Risk in Patients With Rheumatoid Arthritis Treated With Anti-Tumor Necrosis Factor α
福田卓先生:Nature Genet (2008) 40:1402-1403, Nature Genet (2009) 41:854-853
Genetic variation in the KIF1B locus influences suseptibility to multiple sclerosis
佐藤剛先生:Lancet (2009)373:2215-21
“あなたはすでにDM ロードを歩いています。残念ですが。。”
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2
diabetes: ana analysis from Whitehall II study
徳田昌紘先生:N Engl J Med (2009) 36:2066-78
Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation.(The ACTIVE I)

山崎聡士先生:Nature 2009,460:823, Nature 2009,457:467, RNA 2007,13:952, Mol Cell 1998,2:383, J.Biol. Chem. 2001,276:7806, PNAS 2001,98:8780, PNAS 2002,99:4596, Science 2004,306:2090, Cell Metab.2008,8:146, Haematologica 2009,Epub, J Clin Invest. 2007,117:1755, Eur J Cln Invest. 2006,36:301, Nature2009,457:318, J Clin Invest. 2007,117:1755, PNAS 2009,106:3800, Science. 2009,325;877, Cell. 2006,124;587,Science. 2009,325;877, Nat. genet. 2009,41;478 , Nat. genet. 2009,41;482, RNA 2007,13:952.
~27 億年前にさかのぼる、鉄をめぐる生命の争いの歴史に迫る!~
江良愛先生:Thyroid (2008) 18:697-704
Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma.
原口愛先生:J Clin Endocrin Metab (2010)e-pub
“チラージンは、TSH ちょっと抑え気味が、ほどよい!?
Serum Thyroid-Stimulating Hormaone Concentration and Morbidity from Cardiovascular Disease and Fractures in Patients on Long-Term Thyroxine Therapy
高橋慧先生:The New Engl J Med (2009) 361:1139-1151
“心房細動患者でも納豆OK の時代到来!?
Dabigatran versus Warfarin in Patients with Atrial Fibrillation
中田るか先生:Newrology (2009) 72:1548-1554
“MG は日本でもレディーファースト!?”
Incidence and mortality rates of myasthenia graves and myasthenic crisis in US hospitals
赤澤論先生:The New Engl J Med (2009) 361:1339-1348
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes
前田千恵先生:The New Engl J Med (2009) 361:1736-1747
Three-Year efficacy of Complex Insulin Regiments in Type 2 Diabetes;4-T study

伊藤博之先生先生:N Engl J Med (2009) 360:1283-1297
“ICU にDM 専門医はいらない!?
Intensive versus Conventional Glucose Control in Critically Ill Patients; The NICE SUGAR Study
桑原宏永先生:Inter Med. 2008 47:1165-1170, Diabetologia 2006 49:1008-1016,Atherosclerosis Supple 2008
9:77-81, Biochim Biophys Acta 2009 1971:679-683 Molecul Cell Neuroscience 2009 in press
岡田覚丈 先生:Arthritis & Rheumatism (2009) 60:1906-1914
Adipocytokine are associated with radiographic joint damage in Rheumatoid Arthritis
古賀智裕先生:Clin Microbiol Infect (2009) 15:481-487
Antibiotic treatment interruption of suspected lower respiratory tract infections based on a single procalcitonin measurement at hospital admission-a randomized trial
古林正和先生:Nutrition, Metabolism & Cardiovascular Disease (2009) e-pub in press
“いよいよDPP-4 阻害薬の全貌が明らかに!?”
Dipeptydil peptidase-4 inhibitors in type 2 diabetes: A meta-analysis of randomized clinical trials

阿比留教生先生:N Engl J Med 340: 692-702 1999, Immunological Reviews 203: 244-250 2005, Immunity 25: 744-745 2006, Nature 448: 1058-1063 2007, N Engl J Med 357: 1608-1619 2007, Nature 452: 773-777 2008, J Exp Med 205: 1551-1557 2008, Int. immunol. 21: 105-112 2008, J Immunol. 182:21-28 2009, J Exp Med 206: 1291-1301 2009, Current Opinion in Immunology 21: 1-6 2009
Hyper-IgE syndrome -lesson from human multisystem disorder
六倉和生先生:Arch Neurol (2009) 66(3):315-322
Different Patterns of Cerebral Injury in Dementia With or Without Diabetes
湯浅隆行先生:Neurology (2009) 73:862-868
Retinal microvascular abnormalities AND cognitive decline-The ARIC 14 yr follow-up study
西野 文子先生:Arthritis Rheum 56 (12): 3928-3939, 2007.
Van der Heijde D, Klareskog L, Landewe R, et al. Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis.
由良 博一 先生:Lancet 374 (9689): 525-533, 2009.
Verdecchia P, Staessen JA, Angeli F, et al. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
佐々木玲美先生:BMJ (2009) 339:b2462
“死ぬまで婚活のススメ;CAIDE study”
Association between mid-life marital status and cognitive function in later life: population based cohort study
井上大輔先生:J Clin Endocrinol Metab (2008) 93:3416-3424
“成人GH 分泌不全症患者へのホルモン補充療法の抗動脈硬化作用”
Growth hormone treatment ion atherosclerosis: Results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency

宇佐俊郎先生:Ann Intern Med. 144:753-761 2006、日本口腔外科学会雑誌,53,594-602 2007、J Oral Pathol Med. 36:***********、Lancet Oncol 7:***********
日野直之先生:J Neurol Neurosurg Psychiatry (2007) 78:36-42
Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress
中村寛先生:Diabetologia (2008) 51:1631-1638
Alcohol consumption and risk of microvascular complication in type 1 diabetes patients: the EURODIAB Prespective Complication Study

佐藤克也先生:神経感染症. 2008 70(7): 504_511 Ann Neurol. 2005 58(4):594-604 Ann Neurol. 2007 61(1): 25_36.  Neurology. 2008 70(7): 504_511 Lancet Neurol 2008; 7: 1091_98
“またしても、日米対決か!?AJFHE vs 抗NMDA脳炎”
植木郁子先生:N Engl J Med (2009) 361:40-51
Renal and Retinal Effects of Enalapril and Losartan in Type 1 Diabetes
坂井無二子先生:Movement Disorders. (2008) 23:547-552
Decision Making in Parkinsonユs Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task
蒲池誠先生:PNAS (2007) 104:20887
Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma
佐藤剛先生:Diabetologia. (2009) June E-pub
The influence of glucose lowering therapies on cancer risk in type 2 diabetes
立石洋平先生:Stroke (2009) 40:902-908
Long-Term Effects of Specialized Stroke Care With Telemedicine Support in Community Hospitals on Behalf of the Telemedical Project for Integrative Stroke Care (TEMPis)
福田卓先生:Nature. (2007) 448:934-937
An IRF-8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

本村政勝先生:Nat Clin Pract Neurol 3: 405-410, 2007.
川尻真也先生:NEJM(2004) 354: 1425, CHEST (2007) 131: 1917, Ann Rheum Dis.(2004) 63: 1009, Lancet (2008)371: 2093, Arthritis Rheum (2003)48: 516, A&R(2008) 58: 284/, A&R(2009) 60: 569
Scleroderma with Pulmonary Hypertension
徳田昌紘先生:New Engl J Med. (2009) 360:1597-605
Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs
田口正剛先生:JAMA(2009) 301(9): 937-944.
“PPI は、プラビックスの急性冠症候群再発の予防効果を減弱させる”
Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Cronary Syndrome.
中田るか先生:New Engl J Med. (2009) 360(22):2302-2309
Age, Neuropathology, and Dementia

川上純先生:①Arthritis Rheum 58: 3710-3719; 2008. ②Arthritis Rheum 58: 875-887; 2008 ③Ann Intern Med 144: 865-876; 2006 ④N Engl J Med 353: 1114-1123, 2005 ⑤Ann Rheum Dis 67: 1096-1103, 2008
赤澤論先生:Diabetes Care(2007) 30: 1979-1987.
“DPP4 阻害薬+BG2 剤併用は、2 型糖尿病治療のファーストチョイス!?”
Effect of Initial Combination Therapy with Sitagliptin, a DPP-4 inhibitor, and on
Glycemic Control in Patients with Type 2 Diabetes
河久由紀子先生:New Engl J Med. (2009) 360(18):1851-61
JUPITAR trial A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism
小池玄文先生:The Journal of Nuclear Med (2007) 48(6): 889-95.
“甲状腺がんの骨転移検出能PET vs 骨シンチ”
Comparison of 18F-FDG PET and Bone Scintigraphy in Detection of Bone Metastasis of Thyroid Cancer
尾崎方子先生:Arterioscler Thromb Vasc Biol. (2008) 28:629-636 review
Metabolic Syndrome Pandemic
曽根美佳先生:N Engl J Med (2009) 360(16):1606-17.
Valsartan for prevention of recurrent atrial fibrillation.:The GISSI-AF Investigation
古賀智裕先生:Lancet (2009) 373:1253-1263
“ステロイドの骨量減少に、ビスフォス年1 回注射がやたらと効く!”
Zoledronic acid and risedronate in the prevention and treatment of
glucocorticoid-induced osteoporosis (HORIZON):a multicentre, double-blind, double-dummy, randomised controlled trial.

有馬和彦先生:①Journal of Immunology 2000, 165:6635-6643 ②J Clin. Invest. 109:1453-1462 2002 ③Arthritis & Rheumatism 50 (12) 4002-4007, 2004 ④Ann Rheum Dis 2008 Dec E-pub
“SSc and S.S.”
強皮症、CD19 分子を介したB 細胞機能異常とB 細胞標的治療

折口智樹先生:①Arthritis Res Ther 7 (3) R416-23, 2005/ Arthritis Res Ther 10 (6) 410, 2008 ②Neuropeptides 42;133−145、2008 ③Clin Exp Rheumatol 23; 651-657, 2005
“The Inflammation Highway”
村岡徹先生:Gastroenterology (2009) 136:863-871
“PET は見た!肝性脳症の原因、はたまた結果??”
Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrosis and an Acute Episode of Hepatic Encephalopathy
松崎寿久先生:Hepatology (2008) 47:407-417
“C 型肝炎の肝移植治療、HIV 感染者でも大丈夫?!”
Survival and Recurrence of Hepatitis C After Liver Transplantation in Patients
Coinfected with Human Immunodeficiency Virus and Hepatitis C virus
坂井(かよう)無二子先生:Movment disorder (2008) 23:1524-1531.
High-Frequency rTMS over the Supplementary Motor Area for Treatment of Parkinson’s Disease

六倉和生先生:Journal of Neurology (2008) 255:1679-1686
“Microbleeds は、脳梗塞後の脳出血のリスクファクターか?”
Risk vs Benefit of anti-thrombotic therapy in ischemic stroke patients with
cerebral microbleeds
川本真規子先生:Journal of Clinical Oncology (2008) 26:5326-5334.
二度目のアバスチン(Bevacizumab)も効果的“BRiTE study”
Bevacizumab Beyond First Progression is Associated with Prolonged overall Survival in Metastatic Clorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
小澤栄介先生:Hepatology (2009) 49:116-123
“C 型肝炎ウィルス感染、HCC だけでなく、肝内胆管癌や膵癌のリスク上昇”
Risk of Hepatobiliary and Pancreatic Cancers After Hepatitis C Virus Infection
A Population-Based Study of U.S. Veterans
玉井慎美先生:Arthritis & Rheumatism (2008) 58:88-97.
“強直性脊椎炎に対する抗TNF 持続療法”
Maintenance of Infliximab Treatment in Ankylosing Spondylosis
野中文陽先生:N Engl J Med (2008) 359:2641-2650
“RNA 干渉の立役者Dicer Drosha の高発現卵巣がん患者は予後良好”
Dicer Drosha, and Outcomes in Patients with Ovarian Cancer.
植木郁子先生:Diabetes (2009) 58:360-366.
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function

高原靖先生:Aliment Pharmacol Ther. 2008 28(5):574-80/Gastroenterology. 2008 Nov19 [Epub]
“エジプト発、ニタゾキサニドは、本当にC 型肝炎に効くのか?!”
Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4.
中村寛先生:Arch Intern Med (2008) 168(15):1638-1646.
Reduced Disability and Mortality Among Aging Runners
古林正和先生:Diabetes Care (2008) 31:1305-1310.
“2 型糖尿病患者へのカーボカウント応用は肥る”というのは、大嘘!!”
Adjust to target in type 2 diabetes: comparison of a simple algorlthm with carbohydrate counting for adjustment of mealtime insulin glullsine.
安井順一先生:N Engl J Med (2008) 358:1572-1579.
Long-Term Results of Carotid Stenting versus Endarterectomy in High-Risk Patients

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