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１２月２４日（テーマ抄読会） |
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山崎聡士先生
「自己を規定する糖鎖修飾酵素」
1) J Exp Med. 2009; 206:125-38. 2) Trends Immunol. 2009;30: 488-93. 3) Nature. 2010;466: 243-7. 4) Nature. 2010; 466:334-8. 5) 免疫の意味論 （青土社） |
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１２月１７日 |
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林田拓也先生：N Engl J Med(2010) 363: 2211-2219
"肥るべきか、やせるべきか"
Body-Mass Index and Mortality among 1.46 Million White Adults |
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村田芙美先生：BMJ (2010)341：1-11
"どかっーと飲んで、ぽっくり逝こう！"
Pattern of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) |
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１２月１０日 |
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川尻真也先生：Scand J Rhematol (2010) in press、Ann Rheum Dis (2010)69(5):879-882 Rheumatology(2009) 48(12): 1566-1569
"関節エコーとリウマチ性多発筋痛症"
Ultrasonography in early assessment of elderly patients with polymyalgic symptoms: a role inpredicting diagnostic outcome? |
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徳田昌紘先生：Diabetes Care (2008)31：1448-1454
"リリカは効くか？？"
Efficacy, Safty, and Tolerability of Pregabalin Treatment for Painful Diabetic Peripheral Neuropathy |
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１２月３日 |
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湯浅隆行先生：Arch Neurol (2010) 67(10)1187-1194
"幹細胞移植-脳への挑戦！"
Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis |
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中田るか先生：Lancet (2010)376：1741-1750
"アスピリンは、右半結腸癌発症を抑制する"
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomized trials |
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| ２０１０年１１月 |
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１１月２６日（テーマ抄読会） |
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桑原宏永先生
「りんごは、実をかじるな！！～新しい糖尿病薬のお話～」
Nature Reviews/Drug discovery 2010 (9) 551-559 J.Clin. Endocrinol. Metab. 2010 (95), 34-42. Diabetes, Obesity and Metabolism. 2009 (11)79-88, Current Genomics. 2007 (8)113-128, American Journal of Kidney Disease 2009 (53)875-883, DiabetesMetab Res Rev 2005 (21)31-38 J. Clin. Invest. 1994 （93） 397-404, Phytochemistry 2010 (71) 838-843 Nippon Rinnsho 2002 (60), suppl 8520-521 |
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１１月１９日 |
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磯本恵理子先生：N Engl J Med (2010) Aug 28 Epub ahead of print
"海の幸より山の幸か？心筋梗塞患者へのω-3 の二次予防効果"
n-3 Fatty Acids and Cardiovascular Events after Myocardial Infarction |
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村上聡子先生：N Engl J Med (2010)362：101-109
"米兵の妻は、病んでいる！。。 らしい。"
Deployment and Use of Mental Health Services among U.S Army Wives |
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１１月１２日 |
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銕尾智幸先生：N Engl J Med (2010) 363.1704-1714
"プラビックスのテーラーメード医療"
Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment |
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赤澤 諭先生：Lancet (2010) 375.2223-2233
"尿糖をもって糖尿を制す！！"
Effects of dapagliflozon in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomised, double-blind, placebo-controlled trial |
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１１月５日 |
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前原史朋先生：N Engl J Med (2010) 363.905-917
"やせ薬で、死なない程度の苦しみはいかが！？"
Effect of Sibutramine on Cardiovasucular Outcomes in Overweight and Obese Subjects |
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中島好一先生：N Engl J Med (2010) 363.1410-1408
"ACCORD の敵をADVANCE で討てるか！！"
Severe Hypoglycemia and Risks of Vascular Events and Death |
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| ２０１０年１０月 |
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１０月２２日（テーマ抄読会） |
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阿比留教生先生
“脳血流改善薬で、 本当に関節リウマチが治るのか？！
～Rho kinase阻害薬と自己免疫疾患～”
Sato et al.(2000)Circ. Res. 87;195-200 Shimokawa et al. Arterioscler Thromb Vasc Biol. (2005) (9):1767-75 Tawara et al.Yakugaku Zasshi. (2007) (3):501-14 Yamanaka et al. Arthritis Rheum. (2010) 62(1):82-92 Tanaka et al. Arthritis Rheum. (2010) 62(4):952-9 Kira et al. J Neuroimmunol. (2006)(1-2):126-34 Yu et al. Neurosci Res. (2010) (8):1664-72 Chen et al. Immunity. 2008 29(6):899-911 Partha et al. J Clin Invest. (2010); 120(9):3280 |
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１０月１５日 |
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古林正和先生：JAMA. 2010；304: 1350-1357.
“外来患者の心血管イベントリスクの見分け方！”
Comparative Determinants of 4-Year Cardiovascular Event Rates in Stable Outpatients at Risk of or with Atherothrombosis |
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鈴木貴久先生：N Engl J Med (2010) 363.1303-1312
“Syk 阻害薬は、生物学的製剤の次の一手となりうるか！”
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis |
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１０月８日 |
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中村寛先生：J Hypertensi. 2010；28: 1699-1707.
“脂肪肝は、血管を硬くする！”
Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study |
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森良孝先生：Nephrol Dial Transplant (2009) 1-9.
“手術不要、続発性副甲状腺機能亢進症にカルシミメティクス！”
Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperthyroidism |
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| ２０１０年９月 |
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９月２４日（テーマ抄読会） |
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宇佐俊郎先生
“エストロゲン補充療法 ～問題点と今後～”
Nakamura T, Cell. 2007 (130):811-823, N Engl J Med. 1997 (336):1769-1775, JAMA. 2002 (288):221-222, Obstet Gynecol 2009 (113):65-73, JCEM 1999 (84):4559-4565, JAMA 2007 (297): 1465-1477, |
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９月１７日 |
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梅田雅孝先生：Lancet (2010) 375:2234-2243.
“アメリカドクトカゲの世界征服計画-DURATION＃３”
Once weekely exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label rondomised trial |
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高野香菜子先生：N Engl J Med. 2010；363: 233-244.
“厳格な血糖管理は網膜症は減らせたか？ACCORD 研究、続報！”
Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes |
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９月１０日 |
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古賀智裕先生：Ann Rheum Dis (2010) 69:1554-1561.
“抗CCP 抗体における、RA 発症前のEpitope spreading”
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis |
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岡田覚丈先生：N Engl J Med. 2010；363: 743-758.
“中国4 千年の歴史の威力とは？線維筋痛症に太極拳！”
A Randomized Trial of Tai Chi for Fibromyalgia |
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９月３日 |
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吉田真太郎先生：Stroke. 2010；41:1431-1439.
“急性脳虚血患者25 万人の“Golden hour”の現場”
The “Golden Hour” and Acute Brain Ischemia
Presenting Features and Lytic Thearpy in >30,000 Patients Arriving Within 60 Minutes of Stroke Onset |
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湯浅千春先生：New Engl J Med (2010) 362:906-916.
“高脂血症に新薬登場か！？KB2115 の実力とは”
Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated Dyslipidemia |
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| ２０１０年８月 |
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８月２７日（テーマ抄読会） |
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本村政勝先生
「抗MuSK 抗体は本当に重症筋無力症の病原性を持っているのか？」
Erik H, Muscle Nerve. 2010 [Epub], J Clin Neuromuscul Dis. 2009 (2):69-71, Neuromuscul Disord. 2008 (6):443-6, Neurology. 2008 (14):1215-6, J Clin Invvest 2006 (116):1016-24, Journal of Neuroimmunology 2006 (175):107-117, Ann Neurol. 2008 (63): 782-789, Cole RN J Physiol. 2010 Jul 5. [Epub] |
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８月２０日 |
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中島大輔先生：N Engl J MEd. 2010；362(8):686-96.
“Lasofoxifen は壮年女性の救世主！？”
Lasofoxifene in postmenopausal women with osteoporosis.（PERL study） |
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黒濱大和先生：Lancet Neurology (2010) (4):381-90.
“多発性硬化症の分野にも生物学的製剤の本格参入か？”
Daclizumab in active relapsing multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. (CHOICE study) |
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| ２０１０年７月 |
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７月２３日 |
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伊藤文子先生：J Am Coll Cardiol. 2010;55:2319-2327
“肥るほどに、心が震える！”
The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation The Women’s Health Study（WHS） |
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植木郁子先生：Diabetes Care (2010)33:951-957
“GLP-1＋チアゾリジンon メトフォルミンはドリームチームか？”
Effects of Exenatide Plus Rosiglitazone on β-cell Function and Insulin Sensitivity in Subjects with Type 2 Diabetes on Metformin |
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７月１６日 |
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宮崎恭子先生：New Engl J Med. 2010 E-pub
“Real time インスリンポンプの威力！”
Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes-the STAR 3 study |
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川尻真也先生：Arthritis Rheum (2010)62:132-142
“活性型ビタミンD のTh17 分化抑制効果！”
1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis |
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７月９日 |
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荒木智徳先生：Ann Rheum Dis. 2010 (3):510-6
“CTLA-4-Ig による超早期関節リウマチの発症阻止効果は？”
Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept-the ADJUST trial. |
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徳田昌紘先生：Lancet Oncol (2009)9:895-902
“IVL の正体”
Presentation and management of intravascular large B-cell lymphoma |
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| ２０１０年６月 |
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６月２５日（テーマ抄読会） |
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川上純先生
「関節リウマチの治療目標、標準的治療指針、および寛解についての最新の知見」
Smolen JS, Ann Rheum Dis. 2010, Saag K.G., Arthritis Rheum 2008, Smolen JS, Ann Rheum Dis 2010, Tanaka Y, Ann Rheum Dis 2010, Saleem B, Ann Rheum Dis, e-pub, 2010, Brown K,Arthritis Rheum, 2008 |
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６月１８日 |
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太田理絵先生：Lancet Neurol (2010)9:981-991
“パーキンソン病に脳内ペースメーカー、奥深く刺激します！？”
Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease (PD
SURG trial): a randomized, open-label trial |
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村田芙美先生：BMJ(2010)340:6546-6545
“ARB は、高齢男性の救世主か！？”
Use of ARB and risk of dementia in a predominantly male population: prospective cohort analysis |
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６月１１日 |
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梅田雅孝先生：Cancer Science(2010)101:1480-1486
“予後不良！血管内リンパ腫（IVL）に中枢神経病変合併”
Central nervous system involvement in intravascular large B-cell lymphoma: A retrospective analysis of 109 patients |
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中田るか先生：Neurology(2010)74:1351-1357
“ABCD では物足りない！？”
Multicenter external validation of the ABCD2 score in triaging TIA patients |
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| ２０１０年５月 |
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５月２１日 |
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佐藤剛先生：Lancet(2010)375:1147-1156.
“インクレチン製剤のガチンコ対決、さて軍配は？”
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with
metformin: a 26-week, randomized, parallel-group, open-label trial |
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夏田昌子先生：Lancet(2009)374:1677-1686
“長期的にみても、やはり生活習慣介入がDM 発症を予防する”
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study
Diabetes Prevention Program(DPP) study |
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５月１４日 |
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赤澤論先生：N Engl J Med(2010)362: 1463-1476.
“境界型耐糖能異常患者にGlinide は効果なし”
Effect of Nateglinide on the Incidence of Diabetes and Cardiovascular Events
The NAVIGATOR Study Group |
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梶村慈先生：N Engl J Med(2010)362:1563-1574
“2 型糖尿病患者の脂質異常症に、Fenofibrate はAdd-on 効果なし”
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
The ACCORD Study Group |
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５月７日 |
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中島好一先生：Arthritis & Rheumatism(2010)62:1265-1272
“酒は、ＲＡ患者にも百薬の長か？？”
The Effect of Alcohol on Radiographic Progression in Rheumatoid Arthritis |
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渡邊順平先生：(2010)41:674-679
“シスタチンC と無症候性頚動脈硬化症の心血管イベントリスク”
Cystatin C and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis. |
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| ２０１０年４月 |
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４月３０日（テーマ抄読会） |
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折口智樹先生
「慢性炎症疾患が悪性リンパ腫の原因となる遺伝子異常の発見！」
Arima K, Ann Rheum Dis. 2005 641653-5. Nature. 2009 ;459(7247):712-6.
Nature. 2009 459(7247):717-21. Trends Immunol. 2009 Aug;30(8):383-91. |
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４月１６日 |
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渋谷亜矢子先生：Journal of Neuroimmunology(2010)221:68-72
“NMO は、なぜ視神経や脊髄がやられるのか？？”
Differential expression of aquaporin-4 isoforms localizez with neuromyelitis optica disease activity |
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中村寛先生：Diabetologia (2010)53:481-488
“2 型糖尿病は、夜つくられる！？”
Nocturnal intermittent hypoxia and the development of type 2 diabetes: Circulatory Risk in
Communities Study (CIRCUS) |
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| ２０１０年３月 |
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３月１９日 |
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原口愛先生：J Clin Endocrinol Metab (2010)95:e-pub
“2 型糖尿病は、クッシング病予備軍か？”
Elevated Fasting Plasma Cortisol Is Associated with Ischemic Heart Disease and Its Risk Factors in
Peaple with Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study (ET2DS) |
| ● |
岡田覚丈先生：Clin Nucl Med (2009)34:862-868
“不明熱診断の名医、PET 先生！？”
F－18 FDG PET/CT in the Diagnosis of Fever of Unknown Origin |
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３月１２日 |
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古賀智裕先生：Arthritis & Rheumatism (2005)52:2761-2767/ Fertil Steril. (2009)3:694-697.
“リュープリンはSLE 女性の強い味方になるか”
Use of Gonadotropin-Releasing Hormone Analog for Protection Against Premature Ovarian Failure
During Cyclophosphamide Therapy in Women With Severe Lupus |
| ● |
阿部伸一先生：New Engl J Med (2010)362:800-811
“HbA1c による健常者の動脈硬化リスク階層化”
Glycated Hemoglobin, Diabetes, and Cardiovascular Risk in Nondiabetic Adults（ARIC study） |
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３月５日 |
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蒲池誠先生：PNAS (2010)105:14023-14027
“機能的FOXP3 の見分け方”
TGF-b and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 |
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六倉和生先生：Ann Neurol (2009)65:557-568
“最近よく物忘れが、、というあなたの未来を写します。アミロイド-PET！”
Amyloid Imaging in Mild Cognitive Impairment Subtypes |
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| ２０１０年２月 |
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２月２６日（テーマ抄読会） |
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山崎浩則先生
“前駆脂肪細胞は、人生の縮図Part2”
①Nat Rev Rheumatol 137:2009 e-pub
②Journal of Morphology 185:183-193、1985
③MBC Biology 7;38, 2009
④Biol Pharm Bull 32:463-467,2009 |
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２月１９日 |
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井手茜先生：Stroke (2010)41:00-00
“悪玉コレステロール、とにもかくにも下げれば勝ちか！？”
Coronary Heart Disease Risk in Patients With Stroke or Transient Ischemic Attack and No Known
Coronary Heart Disease (SPARCL-Trial 続編) |
| ● |
堤智美先生：ARTHRITIS & RHEUMATISM (2007)56:799-808
“お魚と関節リウマチの新しい関係！？”
Novel Action of n-3 Polyunsaturated Fatty Acids |
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２月５日 |
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植木郁子先生：N Engl J Med (2009)360:859-873
“和食（Japanese 食） 最高！！”
Cpmparison of Weight-Loss Diets with Different Compositions of Fat, Proteinm and Carbohydrates |
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| ２０１０年１月 |
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１月２９日（テーマ抄読会） |
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井田弘明先生
「オートファジ－（Autophagy）と疾患」
～オートファジーはファンタジー～
実験医学26 (2):153,2008, 実験医学27(9) or (18) 2009, 細胞工学28
(5):451,2009,Annu Rev Immunol 27:423 2009,Biochemica et Biophysica Acta 1793:664,2009 Experimental
Neurology 218:247, 2009 Seminars in Immunology 21:334, 2009 N Engl J Med 360: 1785 2009, Nature 456:259
2009 Nature 456:264 2009, Curr. Opin Cell Biol 22:1 2009, Cell 137: 1001 2009, Biochemica et Biophysica Acta
1793:1478,2009 Immunological Reviews 227:189 2009 蛋白核酸酵素51（10） ：1510 2006, Curr. Opin
Immunol 19:87 2007, Nature 455:396 2008, Annu Rev Immunol 27:165 2009 Annu Rev Pathol. Mech Dis 1:297
2006, Circ Res 104:304 2009, Biochemica et Biophysica Acta 1793:1485 2009, Trends in Cell Biology 19:487
2009, Aging Res Rev (in press), Oncogene 27:2276 2008, Curr Opin Cell Biol 20:126 2008, 少年ジャンプ号不明 |
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今週の症例
