長崎大学病院第一内科 Department of Immunology and Rheumatology, Department of Clinical Neuroscience and Neurology, Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences
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過去の抄読会 (2011年)
宮内悠里江先生:New Engl J Med:2011 365(4):327-36.
"No pain, No gain!~Bardoxolone によるCKD治療~"
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
鬼塚浩徳先生:BMJ: 2011, e-pub
Rapid versus standard intravenous rehydration in paediatric gastroenteritis: pragmatic blinded randomized clinical trial.
村田芙美先生:Eur J Clin Invest : 2011, e-pub
Characterization of nonalcoholic fatty liver disease unrelated to the metabolic syndrome.
川尻真也先生:AnnRheumDis: 2011, 70:1726-1732, Rheumatology 2011, 50:1578-1585
"抗NR2 抗体、2 年ぶりに再登場!"
Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus.
徳山鮎子先生:ARTHRITIS & RHEUMATISM: 2011, 63:3613-3624
"ANCA の次は、なんか?"
AC13, a C-Terminal Fragment of Apolipoprotein A-I, Is a Candidate Biomarker for Microscopic Polyangitis
安井順一先生:Circulation: 2011, 124:2056-2064
"アジア人の心臓は Low HDL に弱い"
Isolated Low Levels of High-Density Lipopritein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease

「NO again」
本日使用した論文は、Seimetz M et al. Inducible NOS Inhibition ReversesTobacco-Smoke-Induced Emphysema andPulmonary Hypertension in Mice. Cell 147, 293–305, 2011, 川真也 膠原病性肺高血圧症 Nov 8. 2011.
Varga J et al. JCI. 2007 117, 557-567. Tsutsui M, et al. Pharmacol Ther. 2010;128(3):499-508. Dooley A, et al. Rheumatology 2006;45:676–684. Ruzek MC. et al. Arthritis Rheum 2004, 50, 1319-1331. Artlett CM. et al Arthritis Rheum 2011, 63, 3563–3574. Sappino AP et al. Am J Pathol, 1990. 137, 585-591.
浅井幸先生:New Engl J Med: 2011, 365:1193-1200
Placebo-Controlled Trial of Cystisine for Smoking Cessatioon
根井吾郎先生:Lancet: 2011, e-pub
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
宮崎偵一郎先生:Neurology: 2011, 77:1453-1456
"あなたにもできる??MRI を使わない脳卒中の予後診断"
The crossed leg sign indicates a favorable outcome after severe stroke
根井吾郎先生:Diabetes Care: 2011, 34:1848-1853
Short-Term Intensive Therapy in Newly Diagnosed Type 2 Diabetes Partially Restores Both Insulin Sensitivity and β-cell Function in Subjects With Long-Term Remission
寳來吉郎先生:ARTHRITIS & RHEUMATISM: 2011, 63(7):2021-2030
"SICCA がシッカ症候群に挑む"
Association Between Salivary Gland Histopathologic Diagnoses and Phenotype Features of Sjogren Syndrome Among 1,726 Registry Participants
池岡俊幸先生:N Engl J Med: 2011, 365:1597-1604
Long-Term Persistence of Hormonal Adaptations to Weight Loss

「High and Low, あなたの病院は??」
本日使用した論文は、J Clin Endocrinol Metab, 2011, 96(9):2652-2662. Diabetes Care, 2009 32 (6) : 1119-31. NEJM,2009 360:1283-1297
成田翔平先生:N Engl J Med: 2011, 364:719-729
"BMI=22 が健康は本当か?アジア人100 万人の実態"
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians
古林正和先生:Diabetes Care: 2011, 34:369-374
"DPP-4 阻害薬は、夢の風邪薬!??"
Use of Dipeptidyl Peptidase-4 Inhibitors and Reporting of Infections: A Disproportionality Analysis in the World Health Organization VigiBase

木下梨華子先生:New Engl J Med:2011. 365:993-1003
"Wingspan ステントの敗北"
Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis
西野文子先生:Ann Rheum Dis:2011. Sep 14. [Epub ahead of print]
The prospective association between psychological distress and disease activity in rheumatoid arthritis: a multilevel regression analysis
中村好一先生:New Engl J Med:2011. Aug 11. [Epub ahead of print]
"ICU の経静脈栄養管理は、早めかvs 遅めか?"
Early versus Late Parenteral Nutrition in Critically Ill Adults
岡田覚丈先生:Lancet:2011. Aug 14. [Epub ahead of print]
Minimum amount of physical activity for reduced mortality and extended life expectancy : a prospective cohort study
白石和輝先生:New Engl J Med:2011. Aug 27. [Epub ahead of print]
"Af 患者にアピキサビン、今度こそ納豆OK か!"
Apixaban versus Warfarin in Patients with Atrial Fibrillation: ARISTOLE trial
諸熊治子先生:New Engl J Med:2011 365(4):327-36.
"糖尿病腎症にバルドキソロン、250 億円の価値とは!"
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

本日使用した論文は、Lindstrom JM, et al Neurology. 26:1054-1059 1976. Hoch Wet al Nature Med 7:365-368. 2001. Higuchi O et al Ann Neurol.69:418-22. 2011. Okada K et al. Science. 312:1802-1805, 2006. Beeson D Science. 313:1975-1978 2006. Shiraishi H, Ann Neurol. 57:289-293, 2005. Wu H,et al. Development. 137:1017-33 2010. Review
大森淳子先生:Diabetes Care:2011 34:198-203.
Repeated Episodes of Hypoglycemia as a Potential Aggravating Factor for Preclinical Atherosclerosis in Subjects With Type 1 Diabetes
安井順一先生:JAMA 2010 304(12):1365-1374.
"TSH 値10 は、命の分かれ目!"
Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality
宮崎さつき先生:JAMA:2010 304(20):2253-2262.
" Effects of Aerobic and Resistance Training on Hemoglobin A1c Levels in Patients With Type 2 Diabetes
村田芙美先生:Circulation 2011 123:2226-2235.
Duration of Treatment With Nonsteroidal Anti-inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction
木下梨華子先生:N Engl J Med.:2011 364(25):2392-404.
Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men
川尻真也先生:Ann Rheum Dis: 2009 68:1850-1855.
"Spondyloarthropathy(SpA)に関節エコーは有用か?Dr K の次なる標的"
How to diagnose spondyloarthritis early? Accuracy of peripheral enthesitis detected by power Doppler ultrasonography

宮崎偵一郎先生:Stroke: 2011, 42: 908-912
"Alteplase、100kg 超級打ち止めの是非"
In the Maximum Dose of 90 mg Alteplase Sufficient for Patients With Ischemic Stroke Weighing >100 kg?
濱邊順平先生:Stroke: 2011 42:908-912.
"コーヒー豆知識;その 1 杯が貴女を脳卒中から守ります"
Coffee Consumption and Risk of Stroke in Women
中田るか先生:Neurology: 2011, 76: 1310-1315
"NMO にリツキサンは効くのか?"
Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab
山口順嗣先生:N Engl J Med: 2011 364:1795-1806.
Evidence for Human Lung Stem Cells
蓬莱吉朗先生:JAMA: 2011, 305: 1460-1468
Development of Antidrug Antibodies Against Adalimumabu and Association With Disease Activity and Treatment Failure During Long-term Follow-up
高谷亜由子先生:N Engl J Med: 2011 364(9):829-841.
Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

本日使用した論文は、1)RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4528-32. 2)Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell. 2010 142(5):787-99
本多舞先生:N Engl J Med: 2011, 364: 2189-2129
Weight loss, Exercise, or Both and Physical Function in Obese Older Adults
池岡俊幸先生:N Engl J Med: 2011, 364:719-729
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians
小片真理子先生:Diabetologia: 2011, 54: 749-756
HbA1c levels in schoolchildren with type 1 diabetes are seasonally variable and dependent on weather conditions
野中俊章先生:Lancet Neurol.2010, 9:866-874
"いよいよ 4.5 時間に、alteprase の適応拡大!"
Implementation and outcome of thrombolysis with alreplase 3-4.5 h after an acute stroke :an updated analysis from SITS-ISTR

西野文子先生:N Engl J Med: 2011, 364: 1315-1325
Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease
玉井慎美先生:Ann Rheum Dis.69(7):1310-4 2009/ Ann Rheum Dis.66:184-188 2007/ Ann Rheum Dis.2011 Mar 11 e-pub.
RA and Lipds

中村寛先生:Diabetes Care: 2011, 34: 14-19
Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet PREDIMED-Reus nutrition intervention randomized trial
河野佑介先生:Movement Disorder: 2011, 26:e-pub
Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis
古林正和先生:Diabetologia: 2011, 54: 271-279
The relation of glycemic index fruit consumption to glycaemic control and risk factor for coronary heart disease
鈴木貴久先生:Chest: 2011, 139: 387-394
Nonsteroidal Antiinflammatory Drugs May Affect the Presentation and Course of Community-Acquired Pneumonia
森良孝先生:Diabetes: 2011, 60: 74-79
Changes in Alcohol Consumption and Subsequent Risk of Type 2 Diabetes in Men
諸熊治子先生:N Engl J Med: 2010, 363: 20
"乳児ミルクの介入は、1 型糖尿病自己抗体発現を抑制する"
Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity

「ALS の病態・最近の話題」
1)Kiernan et al. Lancet (2011) 2)Philips et al. Lancet Neurology (2011) vol. 10 (3) pp. 253-263, 3) Bento-Abreu et al. Eur J Neurosci (2010) vol. 31 (12) pp. 2247-65. 4) Neumann et al. Science (2006) vol. 314 (5796)pp. 130-3 5) Sreedharan et al.Science (2008) vol. 319 (5870) pp. 1668-72 6) Maruyama et al. Nature (2010) vol. 465 (7295) pp. 223-6
岡田覚丈先生:Arthritis Care & Research: 2010, 62: 1160-1165
SLE 患者の滋養強壮に! ~ビタミンD 信奉者からのメッセージ~
Change in Vitamin D Levels in Patients With Systemic Lupus Erythematosus: Effects on
Fatigue, Disease Activity, and Damage
原田直樹先生:Lancet: 2011, 377: 31-41
"あらゆる癌に、一日一錠アスピリン" ~アスピリン信奉者からのメッセージ~
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomized trials

古賀智裕先生:N Engl J Med(2010) 363: 2287-2300
"VIP な透析療法"
In-Center Hemodialysis Six Times per Week versus Three Times per Week

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