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Kidney Group
Kidney group of the 2nd Department of Internal Medicine is engaged in
diagnosis, treatment and elucidation of various renal diseases, including
glomerulonephritis, interstitial nephritis, nephrotic syndrome, renal
failure and secondary renal disorders caused by systemic diseases such
as collagen diseases and diabetes mellitus. We work on a study and clinical
activities from the beginning of kidney diseases through to endstage renal
diseases. One of remarkable characteristics of our group is that we carry
out cooperative activities along with Renal Care Unit in our hospital
and a high quality management for renal diseases. Our aim is to establish
the proper diagnostic and therapeutic strategies for the patients suffered
from various kind of renal diseases.
Staff
Assistant Professor: Masanobu Miyazaki;
msnbmiya-ngs@umin.ac.jp
Research Student: Yoshiaki Nishioka, Takuya Kinoshita, Masaya Miyazaki,
Hiroshi Yamashita
Post-graduate Student: Yoko Yoshio, Chisa Jinnouchi, Yoko Obata, Yuka
Nakazawa
Research Student in the city: Ryuichi Ashida, Tayo Kawazu, Waka Hayashi
Representative 5 publications
1. Miyazaki M, Nishino T, Abe K, Furusu A, Koji T, Kohno S: Regulation
of renal extracellular matrix metabolism. Contrib Nephrol 139: 141-155,
2003
2. Ashizawa M, Miyazaki M, Abe K, Furusu A, Isomoto H, Harada T, Ozono
Y, Sakai H, Koji T, Kohno S: Detection of nuclear factor-kB in IgA nephropathy
using Southwestern histochemistry. Am J Kid Dis 42(1): 76-86, 2003
3. Katsushige Abe , Masanobu Miyazaki, Takehiko Koji, Akira Furusu, Shoko
Tsukasaki, Yoshiyuki Ozono, Takashi Harada, Paul K Nakane,Mitsunori Yagame
Y, Masayuki Endoh,Yasuo Nomoto, Hideto Sakai, and Shigeru Kohno.: Intraglomerular
complement C3 synthesis and its activation in IgA nephropathy. Nephron
87: 231-239, 2001
4. Abe K, Miyazaki M, Koji T, Furusu A, Nakamura-Kurashige T, Nishino
T, Ozono Y, Harada T, Sakai H and Kohno S: Enhanced expression of complement
C5a receptor mRNA in human diseased kidney assessed by in situ hybridization.
Kidney Int 60:137-146, 2001
5. Masanobu Miyazaki, Yoshiyuki Ozono, Takashi Harada and Shigeru Kohno:
In situ hybridization for RNA: Nonradioactive probe: Oligo-DNA probe:
Digoxigenin (II) in Molecular Histochemical Techniques edited by T Koji,
p182-195p, Springer Lab Manual, Tokyo, 2000
Weekly Schedule of Kidney Group
-Mondays and Wednesdays: Kidney Specialist OPD Day
-Mondays : Clinical Conference (18:30-)
-Monday to Friday morning (7:30-): Morning ward round
For Inquiries please call us at: 095-849-7282-7285 (Fax: 095-849-7285)
Kidney Group of the 2nd Department of Internal Medicine
-Clinical Site-
Kidney
Kidneys are a pair of horse-bean-shaped organs, which is slightly larger
than fists, situated in the cavity near the spinal column and excrete
waste products of metabolism of the whole body into the form of urine.
They are one of the most important organs for the maintenance of our lives
and are also associated with red blood cells production and bone metabolism
through vitamin D activation.
Urine sample abnormality
Detection of urinary abnormalities, proteinuria and/or hematuria is the
first step to find out kidney diseases, such as primary glomerulonephritis
and secondary renal diseases caused by collagen diseases and diabetes
mellitus. It is important to clarify the causes of urinary abnormalities
and to give appropriate treatment at an early stage for kidney disease,
just as any other diseases.
Renal Biopsy
In our hospital and its related medical institutes within Nagasaki Prefecture,
nephrlogists provide percutaneous renal biopsy to clarify the causes of
urinary abnormalities and renal dysfunction. About 5 to 10 days admission
is usually required for renal biopsy. Renal biopsy is performed under
ultrasonic guidance procedure, using automatic-biopsy-needle. Biopsy procedure
itself requires only about one hour. Since kidney itself is a mass of
blood vessels, the examinees is asked to have complete bed rest at least
6 hours after the procedure.
(Hospitals/ institutes in Nagasaki Prefecture where kidney specialists
(nephrologists) are stationed)
Nagasaki Municipal Geriatric Disease Center, Isahaya Insurance General
Hospital, Omura Municipal Hospital, Sasebo Municipal General Hospital,
Matsuura Municipal Hospital, Hokusho Central Hospital, Goto Central Hospital,
Shuwakai Sakuramachi HospitalÅEClinic, Kenshokai Shinzato Internal
MedicineÅENephroclinic, Inoue Hospital, Saint Francisco Hospital,
Sasebo Central Hospital, Senju Hospital, Izumikawa Hospital
Treatment
When diagnosis is given, the proper treatment for each patient will be
chosen according to the types of renal diseases and degree of the severity.
It includes alimentary therapyÅihigh calorie and low protein mealsÅj,
drug therapy (anti-platelet agent, angiotensin converting enzyme etc.),
plasma exchange therapy (some renal diseases caused by collagen diseases,
rapidly progressive glomerulonephritis, some nephrotic syndrome), peritoneal
dialysis, hemodialysis and so on. High quality of treatment has been provided
for the patients with any renal diseases in our hospital and the related
medical institutes.
Once you have endostage renal failure, you cannot excrete waste products
of metabolism. The procedure to excrete the waste products from your body
is necessary, such as hemodialysis and peritoneal dialysis. Hemodialysis
is usually performed for about 3-4 hours at 2-3 times a week in the outpatient
clinic. For the patients who want to stay in home, we also provide CAPD
(Continuous Ambulatory Peritoneal Dialysis) system.
We gave you a brief introduction about kidney diseases. If you have any
inquiries, please feel free to ask us. It is the important assignment
for us, nephrologists, to study how to prevent patients from kidney diseases
leading renal failure and to delay the induction of dialysis therapy.
For that purpose, it is vital to have early treatment as well as early
diagnosis. Patients with kidney diseases rarely have subjective symptom
till their diseases go very much aggravated. We do recommend those with
abnormal findings in urine in medical-check-up to have early consultation
with nephrologists.
-Our Research Activities-
Our group is engaged in studies for elucidation of pathology by using
such methods as molecular-histochemistry in the three main diseases;
1) IgA nephropathy, 2) diabetic nephropathy and 3) peritoneal sclerosis.
IgA nephropathy
IgA nephropathy is the most common primary glomerulonephropathy in Japan.
We investigate the mechanism of development and progression using human
IgA nephropathy kidney biopsy tissues.
Diabetic nephropathy
Diabetes mellitus is the leading cause of end-stage renal disease in Japan.
Using experimental diabetic models, we investigate the role of macrophage
infiltration in diabetic nephropathy.
Peritoneal sclerosis
Peritoneal dialysis (PD) is one of the beneficial therapies for chronic
renal failure, however, it induces peritoneal sclerosis which causes peritoneal
dysfunctions during long term. To consider the cause of disease and to
establish the effective treatment, we investigate the pathogenesis of
progression of peritoneal fibrosis, including the role of heat shock protein
(HSP) 47, which is a molecular chaperon necessary for production of collagen,
an importance of angiogenesis using experimental model for peritoneal
fibrosis.
Presentation at Conferences
We annually report those results from researches at Japanese Society of
Nephrology, American Society of Nephrology and Japanese Society of Dialysis
Therapy.
Links:
http://www.jsn.or.jp
http://www.jsdt.or.jp
http://www.jds.or.jp
http://www.mh.nagasaki-u.ac.jp/bumon/jinshikkann.htm