| Department of Anatomy and Neurobiology |
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| Representative: Professor Nozomu Mori |
| Outline |
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| The Neurobiology of Aging: Toward the Healthy Long Life Our department essentially contributes to the research and education of neuroanatomy, and our major research interest centers around the structural modifications of neurons in the aging brain. We ought to understand the mechanisms of brain aging and organismal longevity with special focus on neuron-specific genes controlling neuronal structure, survival, and longevity. To approach the questions of brain aging, there are several key issues to be considered including "maintenance and repair of neuronal circuits", "neuroplastiity and synaptic structure", and "protein quality control to protect aggregation". We explore following experimental themes to tackle the key questions in the field of neurobiology of aging, and wish to understand how we could accomplish the healthy long life in the highly aged society. Theme 1: Neuronal activity and cognitive decline in brain aging Theme 2: Loss of neuronal plasticity and oxidative stress in the aged brain Theme 3: Mechanisms of neuronal cell aging and neuroprotection Theme 4: Defects in proteostasis in neuronal aging and neurodegeneration Theme 5: Genes of longevity SELECTED PUBLICATIONS: Baba S, Onga K, Kakizawa S, Ohyama K, Yasuda K, Otsubo H, Scott BW, Burnham WM, Matsuo T, Nagata I, Mori N. Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity. Sci. Rep. Jun 8;6:27511. doi: 10.1038/srep27511. (2016) Kakizawa S, Shibazaki M, Mori N, Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity, Neurobiol. Aging, 33, 535-545 (2012) Mori N, Mori M, Quest for a long life: Paradoxes and essentials of evolving longevity. Acta Med. Nagasaki 56, 73-80 (2011) Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I, FoxO1 is involved in the antineoplastic effect of calorie restriction. Aging Cell. 9, 372-382 (2010) Mori N, Inhee Mook-Jung (eds.) "Aging Mechanisms: Longevity, Metabolism, and Brain Aging" Springer (2105) |
