Research Areas

Department of
Surgery I
Representative:
Professor Takeshi Nagayasu
Surgery I
Outline
Research fields:
Surgical Oncology. Transplantation and Regeneration. Medical Engineering.

Laboratory mission:
Our laboratory has been established to carry out basic and translational research in surgical oncology and organ transplantation using animal models and regenerated organs.

Surgical Oncology: Basic research
・ Signal pathways in cancer cell lines; regulation of epidermal growth factor signals and 5-FU related enzymes
・ Radiation sensitizer for human malignant mesothelioma, pancreatic cancer, and sarcoma
Translational research
Semi-dry dot blot (SDB) method, a novel diagnostic procedure for determining metastasis to lymph nodes
・ Prognostic and predictive markers

Transplantation and Regeneration: Lung Transplantation
・ Preventing ischemia reperfusion injury
・ Immunomodulatory role of adipogenic stromal cells using orthotopic rat lung transplantation models
Tissue Engineering
Bio-3D-printing technology; scaffold-free cylindrical organs have been created including trachea, esophagus, and intestine
Regeneration of the lung and trachea consisted from decellularized scaffolds and epithelial, endothelial and stem cells in rat and swine models

Medical Engineering: Medical devices
Surgical instruments; endoscopic instruments, devices to assist organ transplantation, bio/nano- materials for prevention of surgical infection.
Web site; http://www.mdp.nagasaki-u.ac.jp/hybrid/index_e

Domestic Network:
Tokyo University of Science; Translational Research Center, Research Institute for Science & Technology
Nagoya University; FIRST Research Center for Innovative Nanobiodevices, Graduate School of Engineering
Saga University; Department of Regenerative Medicine and Biomedical Engineering Faculty of Medicine

Global Network:
Yale University; Department of Anesthesia and Biomedical Engineering, New Haven, USA
Columbia University Medical Center; Columbia Center for Translational Immunology, New York, USA
Cincinnati Children’s Hospital Medical Center; Perinatal Institute, Divisions of Neonatology, Cincinnati, OH, USA
Leiden University; Department of Surgery, K6-R Leiden University Medical Center, Leiden, The Netherlands
Delft University; Department of Bio-Mechanical Engineering, Delft, The Netherlands