Research Areas

Department of
Surgery II
Representative:
Professor Susumu Eguchi
Surgery II
Outline
In our department, we have had a basic and translational research about Regenerative medicine, Transplantation, Oncology and Oncological Immunology in recent years.

Regenerative medicine:
Liver : We had a human hepatocyte cell sheet transplantation in mice model to create a human liver regeneration as artificial organ for liver failure. The reconstruction of the bile duct tree by non-parenchymal cells, CLiPs is on progress. (ex, hepatocyte culture on amniotic membrane, etc)
Small intestine and Anal function: We had reported the new created small intestine by tissue-engineered small intestine (TESI). We have a basic research for improving anal function by adipose derived stem cell sheets, electric stimulation in rat model.
Duodenum: Prevention of duodenal perforation after ESD by cell sheet technology in Pig model.
Thyroid: Thyroid cell sheet from human has been progressed to have a thyroid cell transplantation of regenerative therapy for the patients with hypo-thyroid function.

Transplantation:
We have had an organ transplantation (Liver and Pancreas) for end-stage liver disease and pancreatic disease. We have a basic and clinical research about liver regeneration after liver transplantation. Basic research by cell sheet technology about Islet cell transplantation in diabetes rat model has been progressed to improve islet function after islet cell transplantation.

Oncology and Oncological immunology:
We have a basic and clinical research about oncological immunology and oncology. We investigate the immunological and carcinogenesis in various cancer fields. (ex Carcinogenesis in IL10 knock out mouse model, Immuno-tolerance by T-cell receptor)
We had investigated about a carcinogenesis and prevention of biliary carcinoma in hamster model and about a carcinogenesis of hepatocellular carcinoma in the explanted end-stage liver.
In breast cancer, we had investigated the tumor-infiltrating lymphocytes in HER-2 positive ductal carcinoma.