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平成23年業績 (2011年)
 
【国際学会】
  1. Sano K, Atarashi R, Ishibashi D, Fuse T,Nakagaki T, Nishida N. Reconstruction of infectious prion protein in vitro. Prion 2011, Montreal, Canada, May, 2011.
  2. Ishibashi D, Nishida N. Protective Role of Interferon Regulatory Factor 3-Dependent Signaling Against Prion Infection. Prion 2011, Montreal, Canada, May, 2011.
  3. Atarashi R, Satoh K, Sano K, Fuse T, Ishibashi D, Matsubara T, Nakagaki T, and Nishida N. Evaluation of RT-QUIC (real-time quaking-induced conversion) assay for genetic human prion diseases. Prion 2011, Montreal, Canada, May, 2011.
  4. Nakagaki T. FK506 prolongs the survival period in Fukuoka-1 infected mice. Prion 2011, Montreal, Canada, May, 2011.
  5. Homma T, Ishibashi D, Nishida N. Analysis of murine interferon regulatory factor-3 (IRF-3) promoter. IUMS 2011 Meetings of the Three Divisions of the International Union of Microbiological Societies 2011 Sapporo, Sapporo convention center, Hokkaido, September, 2011.
  6. Nakagaki T, Satoh K, Kamatari Y, Atarashi R, Nishida N. FK506 prolongs survival time in prion-infected mice. IUMS 2011 Meetings of the Three Divisions of the International Union of Microbiological Societies 2011 Sapporo, Sapporo convention center, Hokkaido, September, 2011.
  7. Satoh K. Analysis of Biochemical markers and the method of abnormal prion protein in CSF in Human Prion Diseases as Diagnostic markers.. EFNS 2011 Budapest, Hungary, September, 2011.
  8. Matsubara T. Division of cellular and molecular biology. Asian Pacific Prion Symposium 2011 (APPS2011), Hotel Marroad Karuizawa, Nagano, July, 2011.
  9. Takatsuki H. Quantitation of seeding activity of human prion using real-time quaking induced conversion assay. Asian Pacific Prion Symposium 2011 (APPS2011), Hotel Marroad Karuizawa, Nagano, July, 2011.

【国内学会】
  1. 本間拓二郎, 石橋大輔, 西田教行. プリオン感染におけるInterferon regulatory factor-3(IRF-3)遺伝子の発現抑制機序の解明. 第35回長崎感染症研究会, 長崎大学, 長崎, 2011年3月.
  2. Ishibashi D, Yamanaka H, Yamaguchi N, Yamaguchi Y, Nishida N, Sakaguchi S. Immunization with bacterial enzyme succinylarginine dihydrolase induces antigenic mimicry-mediated anti-prion effects in mice. 第40回日本免疫学会総会, 幕張メッセ, 千葉, 2011年11月.
  3. 佐藤克也, 新竜一郎, 調漸, 六倉和生, 西田教行. 日本におけるヒトプリオン病の髄液中のバイオマーカーの検討. 第52回 日本神経学会学術大会, 名古屋国際会議場, 名古屋, 2011年5月.

【原著】
  1. Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med. 17(2):175-178. 2011.
  2. Ando Y, Hojo M, Kanaide M, Takada M, Sudo Y, Shiraishi S, Sumikawa K, Uezono Y. S(+)-ketamine suppresses desensitization of γ-aminobutyric acid type B receptor-mediated signaling by inhibition of the interaction of γ-aminobutyric acid type B receptors with G protein-coupled receptor kinase 4 or 5. Anesthesiology. 114(2):401-411. 2011.
  3. Tsujino A, Kaibara M, Hayashi H, Eguchi H, Nakayama S, Satoh K, Fukuda T, Tateishi Y, Shirabe S, Taniyama K, Kawakami A. A CLCN1 mutation in dominant myotonia congenital impairs the increment of chloride conductance during repetitive depolarization. Neurosci Lett. 494(2):155-160. 2011.
  4. Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S. Effects of a brain-Engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions. Cell Mol Neurobiol.  31(7):999-1008. 2011.
  5. Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Satoh K, Tamai M, Nakamura H, Okada A, Koga T, Yamasaki S, Ida H, Origuchi T, Eguchi K. The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in patients with rheumatoid arthritis. Rheumatology (Oxford). 50(5):962-965. 2011.
  6. Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Uezono Y, Ueta Y. Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. Eur J Pharmacol. 655(1-3):31-37. 2011.
  7. Satoh K, Nakaoke R, Nishiura Y, Tsujino A, Motomura M, Yoshimura T, Sasaki K, Shigematsu K, Shirabe S, Eguchi K. Early detection of sporadic CJD by diffusion-weighted MRI before the onset of symptoms. J Neurol Neurosurg Psychiatry. 82(8):942-943. 2011.
  8. Yokoyama T, Minami K, Sudo Y, Horishita T, Ogata J, Yanagita T, Uezono Y. Effects of sevoflurane on voltage-gated sodium channel Na(v)1.8, Na(v)1.7, and Na(v)1.4 expressed in Xenopus oocytes. J Anesth. 25(4):609-613. 2011.
  9. Takakura I, Miyazawa K, Kanaya T, Itani W, Watanabe K, Ohwada S, Watanabe H, Hondo T, Rose MT, Mori T, Sakaguchi S, Nishida N, Katamine S, Yamaguchi T, Aso H. Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice. Am J Pathol. 179(3):1301-1309. 2011.
  10. Imai S, Sudo Y, Nakamura A, Ozeki A, Asato M, Hojo M, Devi LA, Kuzumaki N, Suzuki T, Uezono Y, Narita M. Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl. Synapse. 65(9):962-966. 2011.
  11. Minami K, Sudo Y, Yokoyama T, Ogata J, Takeuchi M, Uezono Y. Sevoflurane Inhibits the µ-Opioid Receptor Function Expressed in Xenopus Oocytes. Pharmacology. 88(3-4):127-132. 2011.
  12. Koga T, Okada A, Kawashiri S, Kita J, Suzuki T, Nakashima Y, Tamai M, Satoh K, Origuchi T, Iwamoto N, Yamasaki S, Nakamura H, Migita K, Ida H, Ueki Y, Eguchi K, Kawakami A. Soluble urokinase plasminogen activator receptor as a useful biomarker to predict the response to adalimumab in patients with rheumatoid arthritis in a Japanese population. Clin Exp Rheumatol. 29(5):811-815. 2011.
  13. Matsui Y, Satoh K, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishida N. High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease. BMC Neurol. 11:120. 2011.
  14. Ishibashi D, Yamanaka H, Mori T, Yamaguchi N, Yamaguchi Y, Noriyuki N, Sakaguchi S. Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice. Vaccine. 29(50).9321-9328. 2011.

【講演】
  1. Atarashi R. Specificity of Human Prion Detection in CSF. CJD 2011 and the Ninth Annual CJD Foundation Family Conference, Washington, DC. USA, August 2011.

【受賞】
  1. 新竜一郎. 長崎県科学技術賞.

【総説】
  1. Atarashi R, Sano K, Satoh K, Nishida N. Real-time quaking-induced conversion: a highly sensitive assay for prion detection. Prion. 5(3):150-153. 2011.
  2. 佐藤克也, 調漸. 【認知症学 下-その解明と治療の最新知見-】 臨床編 プリオン病の診断と治療 孤発性プリオン病 Kuru. 日本臨床. 69(増刊10 認知症学(下)), pp 423-426, 2011.
  3. 新竜一郎, 佐藤克也. 本年の動向 プリオン病の髄液診断の可能性. Annual Review神経, pp121-129. 2011.
 
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