長崎大学大学院医歯薬学総合研究科 新興感染症病態制御学専攻 感染分子解析学分野

業 績

2023年

  1. Mizuta S, Mosaddeque F, Tun MMN, Teklemichael AA, Taniguchi M, Hosokawa M, Yamaguchi T, Makau J, Huy NT, Mizukami S, Nishida N, Morita K, Hirayama K. Challenges Based on Antiplasmodial and Antiviral Activities of 7-Chloro-4-aminoquinoline Derivatives. ChemMedChem. 2023 Feb 3: e202200586. doi: 10.1002/cmdc.202200586.

2022年

  1. Nakaie M, Katayama F, Nakagaki T, Yoshida S, Kawasaki M, Nishi K, Ogawa K, Toriba A, Nishida N, Nakayama M, Fuchigami T. Synthesis and Biological Evaluation of Novel 2-(Benzofuran-2-yl)-chromone Derivatives for In Vivo Imaging of Prion Deposits in the Brain. ACS Infect Dis. 2022 Sep 9;8(9):1869-1882. doi: 10.1021/acsinfecdis.2c00142.

  2. Otaki H, Taguchi Y, Nishida N. Conformation-Dependent Influences of Hydrophobic Amino Acids in Two In-Register Parallel β-Sheet Amyloids, an α-Synuclein Amyloid and a Local Structural Model of PrPSc. ACS Omega. 2022 Aug 24;7(35):31271-31288. doi: 10.1021/acsomega.2c03523.

  3. Nakagaki T, Kaneko M, Satoh K, Murai K, Saiki K, Matsumoto G, Ogami-Takamura K, Ikematsu K, Akagi A, Iwasaki Y, Tsurumoto T, Nishida N. Detection of Prions in a Cadaver for Anatomical Practice. N Engl J Med. 2022 Jun 9;386(23):2245-2246. doi: 10.1056/NEJMc2204116.

  4. Nakaie M, Katayama F, Nakagaki T, Kawasaki M, Yoshida S, Toriba A, Ogawa K, Nishida N, Nakayama M, Fuchigami T. Synthesis and Characterization of Hydroxyethylamino- and Pyridyl-Substituted 2-Vinyl Chromone Derivatives for Detection of Cerebral Abnormal Prion Protein Deposits. Chem Pharm Bull (Tokyo). 2022;70(3):211-219. doi: 10.1248/cpb.c21-00902.

  5. Mizuta S, Otaki H, Ishikawa T, Makau JN, Yamaguchi T, Fujimoto T, Takakura N, Sakauchi N, Kitamura S, Nono H, Nishi R, Tanaka Y, Takeda K, Nishida N Watanabe K. Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction. J Med Chem. 2022 Jan 13;65(1):369-385. doi: 10.1021/acs.jmedchem.1c01527.

  6. Yamaguchi S, Yoshida M, Horie N, Satoh K, Fukuda Y, Ishizaka S, Ogawa K, Morofuji Y, Hiu T, Izumo T, Kawakami S, Nishida N, Matsuo T. Stem Cell Therapy for Acute/Subacute Ischemic Stroke with a Focus on Intraarterial Stem Cell Transplantation: From Basic Research to Clinical Trials. Bioengineering (Basel). 2022 Dec 27;10(1):33. doi: 10.3390/bioengineering10010033.

2021年

  1. Dong TT, Akagi A, Nonaka T, Nakagaki T, Mihara B, Takao M, Iwasaki Y, Nishida N, Satoh K. Formalin RT-QuIC assay detects prion-seeding activity in formalin-fixed brain samples from sporadic Creutzfeldt-Jakob disease patients. Neurobiol Dis. 2021 Nov;159:105504. doi: 10.1016/j.nbd.2021.105504.

  2. Fuse T, Nakagaki T, Homma T, Tange H, Yamaguchi N, Atarashi R, Ishibashi D, Nishida N. Dextran sulphate inhibits an association of prions with plasma membrane at the early phase of infection. Neurosci Res. 2021 Oct;171:34-40. doi: 10.1016/j.neures.2021.01.004.

  3. Nakagaki T, Nishida N, Satoh K. Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies. Front Aging Neurosci. 2021 Sep 28;13:703984. doi: 10.3389/fnagi.2021.703984.

  4. Roberto R Moraes Barros, Kittisak Thawnashom, Tyler J Gibson, Jennifer S Armistead, Ramoncito L Caleon, Miho Kaneko, Whitney A Kite, J Patrick Mershon, Jacqueline K Brockhurst, Theresa Engels, Lynn Lambert, Sachy Orr-Gonzalez, John H Adams, Juliana M Sá, Osamu Kaneko, Thomas E Wellems. Activity of Plasmodium vivax promoter elements in Plasmodium knowlesi, and a centromere-containing plasmid that expresses NanoLuc throughout the parasite life cycle. Malar J. 2021 Jun 5;20(1):247. doi: 10.1186/s12936-021-03773-4.

  5. Tange H, Ishibashi D, Nakagaki T, Taguchi Y, Kamatari YO, Ozawa H, Nishida N. Liquid-liquid phase separation of full-length prion protein initiates conformational conversion in vitro. J Biol Chem. 2021 Jan-Jun;296:100367. doi: 10.1016/j.jbc.2021.100367.

  6. Honda H, Mori S, Watanabe A, Sasagasako N, Sadashima S, Đồng T, Satoh K, Nishida N, Iwaki T. Abnormal prion protein deposits with high seeding activities in the skeletal muscle, femoral nerve, and scalp of an autopsied case of sporadic Creutzfeldt-Jakob disease. Neuropathology. 2021 Apr;41(2):152-158. doi: 10.1111/neup.12717.

  7. Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, Green A, Haïk S, Kovacs GG, Ladogana A, Llorens F, Mead S, Nishida N, Pal S, Parchi P, Pocchiari M, Satoh K, Zanusso G, Zerr I. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021 Mar;20(3):235-246. doi: 10.1016/S1474-4422(20)30477-4.

2020年

  1. Fuchigami T, Kawasaki M, Watanabe H, Nakagaki T, Nishi K, Sano K, Atarashi R, Nakaie M, Yoshida S, Ono M, Nishida N, Nakayama M. Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain. Nucl Med Biol. 2020 Nov-Dec;90-91:41-48. doi: 10.1016/j.nucmedbio.2020.09.003.

  2. Altieri A, Spiridonov EA, Sivtzev SI, Ishibashi D, Biggi S, Nishida N, Biasini E, Kurkin AV. Generation, optimization and characterization of novel anti-prion compounds. Bioorg Med Chem. 2020 Nov 1;28(21):115717. doi: 10.1016/j.bmc.2020.115717.

  3. Nakagaki T, Ishibashi D, Mori T, Miyazaki Y, Takatsuki H, Tange H, Taguchi Y, Satoh K, Atarashi R, Nishida N. Administration of FK506 from Late Stage of Disease Prolongs Survival of Human Prion-Inoculated Mice. Neurotherapeutics. 2020 Oct;17(4):1850-1860. doi: 10.1007/s13311-020-00870-1.

  4. Ishibashi D, Ishikawa T, Mizuta S, Tange H, Nakagaki T, Hamada T, Nishida N. Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice. Neurotherapeutics. 2020 Oct;17(4):1836-1849. doi: 10.1007/s13311-020-00903-9.

  5. Adachi T, Adachi T, Nakagaki T, Ono S, Hidaka M, Ito S, Kanetaka K, Takatsuki M, Nishida N, Eguchi S. Difference in driver gene expression patterns between perihilar and peripheral intrahepatic cholangiocarcinoma in an experimental mouse model. J Hepatobiliary Pancreat Sci. 2020 Aug;27(8):477-486. doi: 10.1002/jhbp.772.

  6. Ubagai K, Fukuda S, Mori T, Takatsuki H, Taguchi Y, Kageyama S, Nishida N, Atarashi R. Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion. Biochem Biophys Res Commun. 2020 Jun 11;526(4):1049-1053. doi: 10.1016/j.bbrc.2020.03.

  7. Matsubara T, Satoh K, Homma T, Nakagaki T, Yamaguchi N, Atarashi R, Sudo Y, Uezono Y, Ishibashi D, Nishida N. Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca2+ signaling. Biochem Biophys Res Commun. 2020 Apr 30;525(2):447-454. doi: 10.1016/j.bbrc.2020.02.102.

  8. Makau JN, Watanabe K, Otaki H, Mizuta S, Ishikawa T, Kamatari YO, Nishida N. A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants. Viruses. 2020 Mar 19;12(3):337. doi: 10.3390/v12030337.

2019年

  1. Satoh K, Fuse T, Nonaka T, Dong T, Takao M, Nakagaki T, Ishibashi D, Taguchi Y, Mihara B, Iwasaki Y, Yoshida M, Nishida N. Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System. Molecules. 2019 Dec 16;24(24):4601. doi: 10.3390/molecules24244601.

  2. Fuchigami T, Kawasaki M, Koyama R, Nakaie M, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Ono M, Nishida N, Nakayama M. Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain. ACS Infect Dis. 2019 Dec 13;5(12):2003-2013. doi: 10.1021/acsinfecdis.8b00184.

  3. Ishibashi D, Homma T, Nakagaki T, Fuse T, Sano K, Satoh K, Mori T, Atarashi R, Nishida N. Type I interferon protects neurons from prions in in vivo models. Brain. 2019 Apr 1;142(4):1035-1050. doi: 10.1093/brain/awz016.

  4. Yamaguchi K, Kamatari YO, Ono F, Shibata H, Fuse T, Elhelaly AE, Fukuoka M, Kimura T, Hosokawa-Muto J, Ishikawa T, Tobiume M, Takeuchi Y, Matsuyama Y, Ishibashi D, Nishida N, Kuwata K. A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques. Nat Biomed Eng. 2019 Mar;3(3):206-219. doi: 10.1038/s41551-019-0349-8.

  5. Taguchi Y, Otaki H, Nishida N. Mechanisms of Strain Diversity of Disease-Associated in-Register Parallel β-Sheet Amyloids and Implications About Prion Strains. Viruses. 2019 Jan 28;11(2):110. doi: 10.3390/v11020110.

  6. Miyazaki Y, Ishikawa T, Kamatari YO, Nakagaki T, Takatsuki H, Ishibashi D, Kuwata K, Nishida N, Atarashi R. Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging. Mol Neurobiol. 2019 Jan;56(1):367-377. doi: 10.1007/s12035-018-1088-7.

2018年

  1. Aibara N, Ichinose K, Baba M, Nakajima H, Satoh K, Atarashi R, Kishikawa N, Nishida N, Kawakami A, Kuroda N, Ohyama K. Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases. Clin Chim Acta. 2018 Sep;484:26-31. doi: 10.1016/j.cca.2018.05.026.

  2. Makau JN, Watanabe K, Mohammed MMD, Nishida N. Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses. J Med Food. 2018 Aug;21(8):777-784. doi: 10.1089/jmf.2017.4121.

  3. Taguchi Y, Lu L, Marrero-Winkens C, Otaki H, Nishida N, Schatzl HM. Disulfide-crosslink scanning reveals prion-induced conformational changes and prionstrain-specific structures of the pathological prion protein PrPSc. J Biol Chem. 2018 Aug 17;293(33):12730-12740. doi: 10.1074/jbc.RA117.001633.

  4. Yamaguchi S, Horie N, Satoh K, Ishikawa T, Mori T, Maeda H, Fukuda Y, Ishizaka S, Hiu T, Morofuji Y, Izumo T, Nishida N, Matsuo T. Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke. J Cereb Blood Flow Metab. 2018 Jul;38(7):1199-1212. doi: 10.1177/0271678X17731964.

  5. Sano K, Atarashi R, Satoh K, Ishibashi D, Nakagaki T, Iwasaki Y, Yoshida M, Murayama S, Mishima K, Nishida N. Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC. Mol Neurobiol. 2018 May;55(5):3916-3930. doi: 10.1007/s12035-017-0624-1.

2017年

  1. Watanabe K, Ishikawa T, Otaki H, Mizuta S, Hamada T, Nakagaki T, Ishibashi D, Urata S, Yasuda J, Tanaka Y, Nishida N. Structure-based drug discovery for combating influenza virus by targeting the PA-PB1 interaction. Sci Rep. 2017 Aug 25;7(1):9500. doi: 10.1038/s41598-017-10021-w.

  2. Makau JN, Watanabe K, Ishikawa T, Mizuta S, Hamada T, Kobayashi N, Nishida N. Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches. PLoS One. 2017 Mar 8;12(3):e0173582. doi: 10.1371/journal.pone.0173582.

  3. Taguchi Y, Nishida N. Secondary-structure prediction revisited: Theoretical β-sheet propensity and coil propensity represent structures of amyloids and aid in elucidating phenomena involved in interspecies transmission of prions. PLoS One. 2017 Feb 15;12(2):e0171974. doi: 10.1371/journal.pone.0171974.

  4. Kawasaki M, Fuchigami T, Kobashi N, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Nishida N, Nakayama M. Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain. Bioorg Med Chem. 2017 Feb 1;25(3):1085-1093. doi: 10.1016/j.bmc.2016.12.020.

2016年

  1. Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K. Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients. EBioMedicine. 2016 Oct;12:150-155. doi: 10.1016/j.ebiom.2016.08.033.

  2. Ishibashi D, Nakagaki T, Ishikawa T, Atarashi R, Watanabe K, Cruz FA, Hamada T, Nishida N. Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation. EBioMedicine. 2016 Jul;9:238-249. doi: 10.1016/j.ebiom.2016.06.010.

  3. Nakano Y, Akamatsu N, Mori T, Sano K, Satoh K, Nagayasu T, Miyoshi Y, Sugio T, Sakai H, Sakae E, Ichimiya K, Hamada M, Nakayama T, Fujita Y, Yanagihara K, Nishida N. Sequential Washing with Electrolyzed Alkaline and Acidic Water Effectively Removes Pathogens from Metal Surfaces. PLoS One. 2016 May 25;11(5):e0156058. doi: 10.1371/journal.pone.0156058.

  4. Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N. A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion. Sci Rep. 2016 Apr 26;6:24993. doi: 10.1038/srep24993.

2015年

  1. Matsushima H, Kuroki T, Kitasato A, Adachi T, Tanaka T, Hirabaru M, Hirayama T, Kuroshima N, Hidaka M, Soyama A, Takatsuki M, Kinoshita N, Sano K, Nishida N, Eguchi S. Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma. Dig Liver Dis. 2015 Dec;47(12):1067-75. doi: 10.1016/j.dld.2015.08.003.

  2. Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M. Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits.  Sci Rep. 2015 Dec 16;5:18440. doi: 10.1038/srep18440.

  3. Ishibashi D, Homma T, Nakagaki T, Fuse T, Sano K, Takatsuki H, Atarashi R, Nishida N. Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells. PLoS One. 2015 Sep 14;10(9):e0137958. doi: 10.1371/journal.pone.0137958.

  4. Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N. Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS One. 2015 Jun 12;10(6):e0126930. doi: 10.1371/journal.pone.0126930.

  5. Homma T, Ishibashi D, Nakagaki T, Fuse T, Mori T, Satoh K, Atarashi R, Nishida N. Ubiquitin-specific protease 14 modulates degradation of cellular prion protein. Sci Rep. 2015 Jun 10;5:11028. doi: 10.1038/srep11028.

  6. Fukuda Y, Horie N, Satoh K, Yamaguchi S, Morofuji Y, Hiu T, Izumo T, Hayashi K, Nishida N, Nagata I. Intra-Arterial Transplantation of Low-Dose Stem Cells Provides Functional Recovery Without Adverse Effects After Stroke. Cell Mol Neurobiol. 2015 Apr;35(3):399-406. doi: 10.1007/s10571-014-0135-9.

  7. Sano K, Atarashi R, Nishida N. Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion. Prion. 2015;9(4):237-43. doi: 10.1080/19336896.2015.1062201.

2014年

  1. Sano K, Atarashi R, Ishibashi D, Nakagaki T, Satoh K, Nishida N. Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion. J Virol. 2014 Oct;88(20):11791-801. doi: 10.1128/JVI.00585-14.

  2. Homma T, Ishibashi D, Nakagaki T, Fuse T, Sano K, Satoh K, Atarashi R, Nishida N. Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3. Sci Rep. 2014 Aug 8;4:6006. doi: 10.1038/srep06006.

  3. Nakamura T1, Satoh K, Fukuda T, Kinoshita I, Nishiura Y, Nagasato K, Yamauchi A, Kataoka Y, Nakamura T, Sasaki H, Kumagai K, Niwa M, Noguchi M, Nakamura H, Nishida N, Kawakami A. Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease. J Neurovirol. 2014 Jun;20(3):269-77. doi: 10.1007/s13365-014-0244-8.

  4. Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, Nishida N. Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein. Sci Rep. 2014 Mar 28;4:4504. doi: 10.1038/srep04504.

  5. Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R. Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. Prion. 2014;8(4):314-8. doi: 10.4161/pri.32081.

2013年

  1. Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R. FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy. 2013 Sep;9(9):1386-94. doi: 10.4161/auto.25381.

  2. Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. doi: 10.1371/journal.pone.0060023.

  3. Ishizaka S, Horie N, Satoh K, Fukuda Y, Nishida N, Nagata I. Intra-arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke. Stroke. 2013 Mar;44(3):720-6. doi: 10.1161/STROKEAHA.112.677328.

  4. Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai H, Mizusawa H, Schmitz M, Zerr I, Kim YS, Nishida N. Early Detection of Abnormal Prion Protein in Genetic Human Prion Diseases Now Possible Using Real-Time QUIC Assay. PLoS One. 2013;8(1):e54915. doi: 10.1371/journal.pone.0054915.

2012年

  1. Ishibashi D, Atarashi R, Nishida N. Protective role of MyD88-independent innate immune responses against prion infection. Prion. 2012 Nov-Dec;6(5):443-6. doi: 10.4161/pri.22579.

  2. Sudo Y, Hojo M, Ando Y, Takada M, Murata H, Kurata S, Nishida N, Uezono Y. GABA(B) receptors do not internalize after baclofen treatment, possibly due to a lack of β-arrestin association: study with a real-time visualizing assay. Synapse. 2012 Sep;66(9):759-69. doi: 10.1002/syn.21565.

  3. Nakato G, Hase K, Suzuki M, Kimura M, Ato M, Hanazato M, Tobiume M, Horiuchi M, Atarashi R, Nishida N, Watarai M, Imaoka K, Ohno H. Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor. J Immunol. 2012 Aug 15;189(4):1540-4. doi: 10.4049/jimmunol.1103332.

  4. Ishibashi D, Atarashi R, Fuse T, Nakagaki T, Yamaguchi N, Satoh K, Honda K, Nishida N. Protective role of interferon regulatory factor 3-mediated signaling against prion infection. J Virol. 2012 May;86(9):4947-55. doi: 10.1128/JVI.06326-11.

  5. Kubota T, Hamazoe Y, Hashiguchi S, Ishibashi D, Akasaka K, Nishida N, Katamine S, Sakaguchi S, Kuroki R, Nakashima T, Sugimura K. Direct evidence of generation and accumulation of β-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for β-form prion protein. J Biol Chem. 2012 Apr 20;287(17):14023-39. doi: 10.1074/jbc.M111.318352.

2011年

  1. Ishibashi D, Yamanaka H, Mori T, Yamaguchi N, Yamaguchi Y, Nishida N, Sakaguchi S. Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice. Vaccine. 2011 Nov 21;29(50):9321-8. doi: 10.1016/j.vaccine.2011.10.017.

  2. Matsui Y, Satoh K, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishida N. High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease. BMC Neurol. 2011 Oct 4;11:120. doi: 10.1186/1471-2377-11-120.

  3. Takakura I, Miyazawa K, Kanaya T, Itani W, Watanabe K, Ohwada S, Watanabe H, Hondo T, Rose MT, Mori T, Sakaguchi S, Nishida N, Katamine S, Yamaguchi T, Aso H. Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice. Am J Pathol. 2011 Sep;179(3):1301-9. doi: 10.1016/j.ajpath.2011.05.058.

  4. Atarashi R, Sano K, Satoh K, Nishida N. Real-time quaking-induced conversion: A highly sensitive assay for prion detection. Prion. 2011 Jul-Sep;5(3):150-3. doi: 10.4161/pri.5.3.16893.

  5. Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med. 2011 Feb;17(2):175-8. doi: 10.1038/nm.2294.

2010年

  1. Miyazawa K, Kanaya T, Takakura I, Tanaka S, Hondo T, Watanabe H, Rose MT, Kitazawa H, Yamaguchi T, Katamine S, Nishida N, Aso H. Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model. J Virol. 2010 Dec;84(23):12285-91. doi: 10.1128/JVI.00969-10.

  2. Satoh K, Tobiume M, Matsui Y, Mutsukura K, Nishida N, Shiga Y, Eguhchi K, Shirabe S, Sata T. Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt-Jakob disease. Lab Invest. 2010 Nov;90(11):1637-44. doi: 10.1038/labinvest.2009.68.

  3. Matsui Y, Satoh K, Mutsukura K, Watanabe T, Nishida N, Matsuda H, Sugino M, Shirabe S, Eguchi K, Kataoka Y. Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients. Cell Mol Neurobiol. 2010 Oct;30(7):991-9. doi: 10.1007/s10571-010-9529-5.

  4. Shimada T, Yamaguchi N, Nishida N, Yamasaki K, Miura K, Katamine S, Masuzaki H. Human papillomavirus DNA in plasma of patients with HPV16 DNA-positive uterine cervical cancer. Jpn J Clin Oncol. 2010 May;40(5):420-4. doi: 10.1093/jjco/hyp193.

2009年

  1. Shigematsu K, Nishida N, Sakai H, Igawa T, Toriyama K, Nakatani A, Takahara O, Kawai K. Synaptophysin immunoreactivity in adrenocortical adenomas: a correlation between synaptophysin and CYP17A1 expression. Eur J Endocrinol. 2009 Dec;161(6):939-45. doi: 10.1530/EJE-09-0596.

  2. Fujihara A, Atarashi R, Fuse T, Ubagai K, Nakagaki T, Yamaguchi N, Ishibashi D, Katamine S, Nishida N. Hyperefficient PrPSc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique. FEBS J. 2009 May;276(10):2841-8. doi: 10.1111/j.1742-4658.2009.07007.x.

  3. Shigematsu K, Nishida N, Sakai H, Igawa T, Suzuki S, Kawai K, Takahara O. Primary aldosteronism with aldosterone-producing adenoma consisting of pure zona glomerulosa-type cells in a pregnant woman. Endocr Pathol. 2009 Spring;20(1):66-72. doi: 10.1007/s12022-009-9060-8.

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