HOME>Staff>Professor: Noriyuki Nishida, MD, PhD

Professor: Noriyuki Nishida, MD, PhD
 Aria of study: Pathogenesis of prion diseases, especially on:

(1) Analysis of strain diversity of prions using cell culture models
(2) Drug-discovery for prion diseases
(3) Decontamination of prion


- Date of Birth:
Feb. 23. 1965; Fukuoka, Japan
- Education:
March 1991: MD, Ryukyu University School of Medicine
March 1997: PhD (Virology), Nagasaki University Graduate School of Medicine
- Clinical training:
1991-1993: Nagasaki University Hospital (Internal medicine)
- Research experience:
1997-1999: JSPS Research fellow, Nagasakai University School of Medicine
1998-2000: Postdoc, Institut de Génétique Humaine - CNRS Montpellier, France
2001-2005: Assistant Professor, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
2005-2006: Associate Professor, Center for Emerging Diseases, Gifu University
2003-2006: Visiting Associate Professor, Department of Surgery Neuropathology, Yale University School of Medicine, USA
April 2006- present: Associate Professor, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

 Recent publications:
  1. Kuwata K, Nishida N, et al. Hot spots in prion protein for pathogenic conversion. Proc Natl Acad Sci U S A. 2007.17;104(29):11921-6
  2. Atarashi R, Sim VL, Nishida N, Caughey B, Katamine S.Prion strain-dependent differences in conversion of mutant prion proteins in cell culture.J Virol. 2006 Aug;80(16):7854-62.
  3. Nishida N., S. Katamine, and L. Manuelidis, Reciprocal interferencebetween specific CJD and scrapie agents in neural cell cultures: Science, 2005, 310, 493-6.
  4. Arima, K., N. Nishida, et al. Biological and biochemical characteristics of prion strains conserved in persistently infected cell cultures: J Virol, 2005, v. 79, 7104-12.
  5. Arjona, A., L. Simarro, F. Islinger, N. Nishida, and L. Manuelidis. Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci U S A 2004. 101:8768-73.
  6. Nishida N, Harris DA, Vilette D, Laude H, Frobert Y, Grassi J, Casanova D, Milhavet O, Lehmann S. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol. 2000 Jan; 74(1):320-5.
  7. Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T. Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene. Nature. 1996 Apr 11;380(6574):528-31.
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