Molecular Epidemiology of Infectious Diseases-Division of Molecular Epidemiology
Professor: Osamu Nakagomi, M.D., Ph.D. (male)
Professor emeritus, Akita University (since 2003) Professor (honorary member) of Medical Microbiology and Genitourinary Medicine, The University of Liverpool, United Kingdom (2004-2007)


 Project I. Molecular epidemiology of rotaviruses from the perspective of tropical medicine.
  Rotavirus infection is one of the most important causes of mortality among the children under 5 years old in the developing world, including most tropical countries. Rotavirus was placed at the top of the emerging viruses list when human rotavirus was discovered in 1973. Within the expanded framework of the 21st century COE program of the Graduate School of Biomedical Sciences and the Institute of Tropical Medicine, Nagasaki University, we are currently working on studies to determine the occurrence of rotavirus disease in various regions of the world, including Asia (Nepal, Bangladesh, Sri Lanka, Vietnam, Thailand), the Middle East (Turkey, Iraq, Saudi Arabia), Africa (Malawi), South America (Brazil), and Europe (UK). In addition, we are characterizing the diversity of the circulating strains, in order to map out a viable preventive strategy against rotavirus disease.
  1. Gentsch JR, Laird AR, Bielfelt B, Griffin DD, Banyai K, Ramachandran M, Jain V, Cunliffe NA, Nakagomi O, Kirkwood CD, Fischer TK, Parashar UD, Bresee JB, Jiang B, Glass RI. Serotype Diversity and Reassortment between Human and Animal Rotavirus Strains: Implications for Rotavirus Vaccine Programs. Journal of Infectious Diseases (in press).
  2. Laird, A.R., Gentsch, J.R., Nakagomi, T., Nakagomi, O., Glass, R.I. Characterization of serotype G9 rotavirus strains isolated in the United States and India 1993-2001. Journal of Clinical Microbiology 41: 3100-3111, 2003
  3. Nakagomi, T., Gentsch, J.R., Das, B.K., Kumar, R., Bhan, M.K., Glass, R.I., *Nakagomi, O. Molecular characterization of serotype G2 and G3 human rotavirus strains that have an apparently identical electropherotype of the short RNA pattern. Archives of Virology 147: 2187-2195, 2002
Project II. Molecular epidemiology of rotaviruses from the perspective of interspecies transmission.
  Rotaviruses have been recovered from a broad range of mammalian and avian hosts. Thus, the interrelationship between human and animal rotaviruses is of great interest from medical as well as evolutionary points of view. Molecular epidemiological studies have revealed that rotaviruses cross species barriers by genetic reassortment and as whole virions.
  1. Nakagomi O, Nakagomi T: Genomic relationships among rotaviruses recovered from various animal species as revealed by RNA-RNA hybridization assays. Res Vet Sci 73: 207-214, 2002 (review)
  2. Nakagomi O, Nakagomi T: Molecular epidemiology of human rotaviruses: genogrouping by RNA-RNA hybridization. Arch Virol [Suppl] 12: 93-98, 1996 (review)
  3. Nakagomi O, Nakagomi T: Interspecies transmission of rotaviruses studied from the perspective of genogroup. Microbiol Immunol 37: 337-348, 1993 (review)