理研　有賀純チーム(比較神経発生/行動発達障害研究チーム　2004-2013)の研究紹介

 
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主要論文

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*, これらの論文では有賀が責任著者です。


  1. Kabayama M, Sakoori K, Yamada K, Ornthanalai VG, Ota M, Morimura N, Katayama K, Murphy NP, Aruga J. Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses. J Neurosci. 33:12940-12953. doi: 10.1523/JNEUROSCI.5717-12.2013 (2013)* 解説
  2. Tekin　M, Chioza　BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster II J, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia X-J, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH. SLITRK6 mutations cause myopia and deafness in humans and mice. J. Clin. Invest. doi: 10.1172/JCI65853 (2013)* 解説.
  3. Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H. Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139:3926-3937. (2012)
  4. Mashiko H, Yoshida A, Kikuchi S, Niimi K, Takahashi E, Aruga J, Okano H, Shimogori T. Comparative anatomy of marmoset and mouse cortex from genomic expression. J. Neurosci. 32:5039-5053. (2012)
  5. Takahashi H, Katayama K-i, Sohya K, Miyamoto H, Prasad T, MatsumotoY, Ota M, Yasuda H, Tsumoto T, Aruga J, Craig AM. Selective control of inhibitory synapse development　by Slitrk3-PTPdelta trans-synaptic interaction. Nat. Neurosci., doi: 10.1038/nn.3040 (2012)* 解説
  6. Fujimi TJ, Hatayama M, Aruga J. Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway. Dev. Biol. doi:10.1016/j.ydbio.2011.10.026 (2012)* 解説
  7. Hatayama M, Aruga J. GLI protein nuclear localization signal.  Vitamins and Hormones　 88:73-89. (2012)*
  8. Takashima N, Odaka, YS, Sakoori K, Akagi T, Hashikawa T, Morimura N, Yamada K, Aruga J. Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia. PLoS ONE 6, e22716. doi:10.1371/journal.pone.0022716 (2011)* 解説 OpenAccess
  9. Hatayama M, Ishiguro A, Iwayama Y, Takashima N, Sakoori K, Toyota T, Nozaki Y, Odaka, YS, Yamada K, Yoshikawa T, Aruga J. Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients. Sci. Rep. 1: 16. DOI:10.1038/srep00016 (2011)* 解説　OpenAccess
  10. Hatayama M, Mikoshiba K, Aruga J. IP3 signaling is required for cilia formation and left–right body axis determination in Xenopus embryos. Biochem Biophys Res Commun. DOI:10.1016/j.bbrc.2011.06.014  (2011)*
  11. Aruga J, Mikoshiba K. Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation. Neurochem Res DOI: 10.1007/s11064-011-0422-5 (2011)* OpenAccess
  12. Matsumoto Y, Katayama K, Okamoto T, Yamada K, Takashima N, Nagao S, Aruga J. Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice. PLoS ONE 6: e16497. doi:10.1371/journal.pone.0016497 (2011)* 解説 OpenAccess
  13. Pan H, Gustafsson MK, Aruga J, Tiedken JJ, Chen J, Emerson CP  Jr. A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. Dev Biol. (2011) [Epub ahead of print] doi:10.1016/j.ydbio.2010.12.037
  14. Maekawa M, Iwayama Y, Watanabe A, Nozaki Y, Ohnishi T, Ohba H, Toyoshima M,　Hamazaki K, Osumi N, Aruga J, Yoshikawa T. Excessive ingestion of long-chain　polyunsaturated fatty acids during developmental stage causes strain- and　sex-dependent eye abnormalities in mice. Biochem Biophys Res Commun. 402:431-437 (2010)
  15. Hatayama, M., Aruga, J. Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions. BMC Evol. Biol. [Epub ahead of print] (2010)* 解説 OpenAccess
  16. Aruga, J, Nozaki, Y., Hatayama, M., Odaka, Y.S., Yokota, N. Expression of ZIC family genes in meningiomas and other brain tumors. BMC Cancer [Epub ahead of print] (2010) *　解説　OpenAccess
  17. Katayama, K-i.,  Zine, A., Ota, M., Matsumoto, Y., Inoue, T., Fritzsch, B., Aruga, J. Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice. PLoS ONE 4, e7786 (2009)* 解説 OpenAccess
  18. Sakai-Kato, K., Umezawa, Y., Mikoshiba, K., Aruga, J., Utsunomiya-Tate, N. Stability of folding structure of Zic zinc finger proteins. Biochem Biophys Res Commun. 384:362-365 (2009)*
  19. Kinameri, E., Inoue, T., Aruga, J., Imayoshi, I., Kageyama, R., Shimogori, T., Moore, A.W.: Prdm proto-oncogene transcription factor family expression and interaction with the Hes/Notch pathway in mouse neurogenesis. PLoS ONE 3, e3859 (2008) OpenAccess
  20. Katayama, K-i, Yamada, K., Ornthanalai, V. G., Inoue, T., Ota, M., Murphy, N.P., Aruga, J.: Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Mol. Psychiatry [Epub ahead of print] (2008)* 解説
  21. Hatayama, M., Tomizawa, T., Sakai-Kato, K., Bouvagnet, P., Kose, S., Imamoto, N., Yokoyama, S., Utsunomiya-Tate, N., Mikoshiba, K., Kigawa, T., Aruga, J.: Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain, a role of conserved tryptophan residue in the zinc finger domain. Hum. Mol. Genet.17, 3459-3473 (2008) * 解説 OpenAccess
  22. Takahashi, H., Shimizu, T., Aruga, J.: Expression pattern of annelid Zic in embryonic development of the oligochaete Tubifex tubifex. Dev. Genes Evol. 218, 553-560. (2008)*
  23. Fujimi, T.J., Aruga, J.: Upstream Stimulation Factors, USF1 and USF2 are differentially expressed during Xenopus embryonic development. Gene Expr. Patterns 8, 376-381. (2008)*
  24. Inoue, T., Ogawa, M., Mikoshiba, K., Aruga J.: Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J. Neurosci. 28, 4712-4725. (2008)*解説 OpenAccess
  25. Ogawa,　M., Mizugishi, K., Ishiguro, A., Koyabu, Y., Imai, Y., Takahashi, R., Mikoshiba, K., Aruga, J.: Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Genes Cells 13, 391-409. (2008)*
  26. Ishiguro, A., Aruga, J.: Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett. 582, 154-158. (2008)*
  27. Sakai-Kato, K., Ishiguro, A., Mikoshiba, K., Aruga, J., and Utsunomiya-Tate, N.: A comprehensive study of the structural dynamics of Zic family proteins, C2H2-type zinc finger proteins, and their relationships with Gli/Glis family proteins. Biochem. Biophys. Acta 1784, 1011-1019. (2008)*
  28. Takahashi, H., Kamiya, A., Ishiguro, A., Suzuki, A.C., Saitou, N., Toyoda, A., Aruga, J.: Conservation and diversification of Msx protein in metazoan evolution. Mol. Biol. Evol. 25, 69-82. (2008)*解説 OpenAccess
  29. Aruga, J., Odaka, Y.S., Kamiya, A., Furuya, H.: Dicyema Pax6 and Zic, tool-kit genes in a highly simplified bilaterian. BMC Evol. Biol. 7, 201 (2007)*解説 OpenAccess
  30. Inoue, T., Ota, M., Ogawa, M., Mikoshiba, K., Aruga, J.: Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J. Neurosci. 27, 5461-5473. (2007)* OpenAccess
  31. Inoue, T., Ota, M., Mikoshiba, K., Aruga, J.: Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev. Biol. 306, 669-684. (2007)*
  32. Aruga, J., Yoshikawa, F., Nozaki, Y., Sakaki, Y., Toyoda, A., Furuichi, T.: An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. J. Neurochem. 102, 1533-1547. (2007)*
  33. Ishiguro, A., Ideta, M., Mikoshiba, K., Chen, D.J., Aruga, J.: Zic2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase and RNA helicase A. J. Biol. Chem. 282, 9983-9995. (2007)*
  34. Yamada, K., Gerber, D. J. Iwayama, Y., Ohnishi, T., Ohba, H., Toyota, T., Aruga, J., Minabe, Y., Tonegawa, S., Yoshikawa, T.: Genetic analysis of the calcineurin pathway identifies the EGR gene family and specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. USA 104, 2815-2820. (2007)
  35. Chhin, B., Hatayama, M., Bozon, D., Ogawa, M., Schön, P., Tohmonda, T. Sassolas, F., Aruga, J., Valard, A-G., Chen, S-C., Bouvagnet, P.: Elucidation of penetrance variability of a ZIC3 mutation in A family with complex heart defects and functional, analysis of ZIC3 mutations in the first zinc finger domain. Human Mutation 28, 563-570. (2007)
  36. Aruga, J., Kamiya, A., Takahashi, H., Fujimi, T.J., Shimizu, Y., Ohkawa, K., Yazawa, S., Umesono, Y., Noguchi, H., Shimizu, T., Saitou, N., Mikoshiba, K., Sakaki, Y., Agata, K., Toyoda, A.: A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity. Genomics 87, 783-792. (2006)*解説
  37. Fujimi, T.J., Mikoshiba, K., Aruga, J.: Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family. Dev Dyn. 235, 3379-3386. (2006)*
  38. Morimura, N., Inoue, T., Katayama, K., Aruga, J.: Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene 380, 72-83. (2006)*
  39. Futatsugi, A., Nakamura, T., Yamada, M.K., Ebisui, E., Nakamura, K., Uchida, K., Kitaguchi, T., Takahashi-Iwanaga, H., Noda, T., Aruga, J., Mikoshiba, K.: IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309, 2232-2234. (2005)
  40. Ishiguro, A., Inoue, T., Mikoshiba, K., Aruga, J.: Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem. Biophys. Res. Commun. 324, 302-307. (2004)*
  41. Aruga, J., Ogura, H., Shutoh, F., Ogawa, M., Franke, B., Nagao, S., Mikoshiba, K.: Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent-tail) mutant mice. Eur. J. Neurosci. 20, 2159-2167. (2004)*
  42. Aruga, J.: The role of Zic genes in neural development. Mol. Cell. Neurosci. 26, 205-221. (2004)*
  43. Inoue, T., Hatayama, M., Tohmonda, T., Itohara, S., Aruga, J., Mikoshiba, K.: Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.　Dev. Biol. 270, 146-162. (2004)*
  44. Mizugishi, K., Hatayama, M., Tohmonda, T., Ogawa, M., Inoue, T., Mikoshiba, K., Aruga, J.: Myogenic repressor I-mfa interferes with the function of Zic family proteins.　Biochem. Biophys. Res. Commun. 320, 233-240. (2004)*
  45. Herrera, E., Brown, L., Aruga, J., Rachel, R.A., Dolen, G., Mikoshiba, K., Brown, S. and Mason, C.A.: Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell 114, 545-557. (2003)
  46. Aruga, J., Mikoshiba, K.: Identification and characterization of Slitrk, a novel neruonal transmembrane protein family controlling neurite outgrowth. Mol. Cell. Neurosci. 24, 117-129. (2003)*
  47. Aruga, J., Yokota, N., Mikoshiba, K.: Human SLITRK family genes, genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 315, 87-94 (2003)*
  48. Aruga, J.: Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr. Patterns 3, 727-733. (2003)*
  49. Hoshino, J., Aruga, J., Ishiguro, A., Mikoshiba, K.: Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Mol. Brain Res. 120, 57-64 (2003)*
  50. Aruga, J., Tohmonda, T., H.omma S., and Mikoshiba K.: Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev. Biol. 244, 329-341. (2002)*
  51. Aruga, J., Inoue, T., Hoshino, J. and Mikoshiba, K.: Zic2 controls the cerebellar development in cooperation with Zic1. J. Neurosci. 22, 218-225. (2002)*
  52. Kitaguchi, T., Mizugishi, K., Hatayama, M., Aruga, J. and Mikoshiba, K.: Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev. Growth Diff. 44, 55-61. (2002)*
  53. Koyabu, Y., Nakata, K., Mizugishi, K., Aruga, J. and Mikoshiba, K.: Physical and functional interaction between Zic and Gli proteins. J. Biol. Chem. 276, 6889-6892. (2001)*
  54. Mizugishi, K., Aruga, J., Nakata, K., Mikoshiba, K.: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 276, 2180-2188. (2001)*
  55. Salero, E., Perez-Sen, R., Aruga, J., Gimenez and, C. and Zafra, F.: Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. J. Biol. Chem. 276, 1881-1888. (2001)*
  56. Maeda, R., Mood, K., Jones, T.L., Aruga, J., Buchberg, A.M., Daar I.O.: Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos. Oncogene 20, 1329-1342. (2001)
  57. Ogura, H., Aruga, J., Mikoshiba, K.: Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders. Behav. Genet. 31, 317-324. (2001)*
  58. Kitaguchi, T., Nakata, K., Nagai, T., Aruga, J. and Mikoshiba, K.: Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev. Genes Evol. 211, 309-314. (2001)*
  59. Tamura, T., Hashimoto, M., Aruga, J., Konish, Y., Nakagawa, M., Ohbayashi, T., Shimada, M., Mikoshiba, K.: Promoter structure and gene expression of the mouse inositol 1,4,5-trisphosphate receptor type 3 gene.　Gene　275, 169-176. (2001)
  60. Nagai, T., Aruga, J., Minowa, O., Sugimoto, T., Ohno, Y., Noda T. and Mikoshiba, K.:Zic2 regulates the kinetics of neurulation. Proc. Natl. Acad. Sci. USA 97, 1618-1623. (2000)*
  61. Kitaguchi, T., Nagai, T., Nakata, K. Aruga, J., Mikoshiba, K.: Zic3 is involved in the left-right asymmetry as a left signal mediator in Xenopus embryo. Development 127, 4787-4795. (2000)*
  62. Nakata, K., Koyabu, Y., Aruga, J., Mikoshiba, K.: A novel member of Xenopus Zic family, Zic5, specifically mediates neural crest development. Mech. Dev. 99, 83-91 (2000)*
  63. Aruga, J., Shimoda, K. and Mikoshiba, K.: A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord. Mol. Brain Res. 78, 15-25. (2000)*

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