Nagasaki University School of MEDICAL SCIENCES

Research Areas

Department of
Gastroenterology and Hepatology

Professor Kazuhiko Nakao

Gastroenterology Reserach:
Our clinical studies include new biomarkers for activity of inflammatory bowel diseases, features of H. pylori-negative gastric cancers, as well as studies related to endoscopic submucosal resection therapy for early esophageal, gastric, and colon. For example, we have recently shown that attachment of polyglycolic acid felt on the post-ESD ulcers prevents bleeding complications in antithrombotic patients. We also perform detailed clinical research on esophageal achalasia and photodynamic diagnosis for early cancers. Our basic research focus on inflammatory bowel diseases and H.pylori-induced apoptosis of gastric epithelium and its mechanisms. For example, we have recently found that H.pylori toxin VacA promote apoptosis of gastric epithelial cells via endoplasmic stress.

Hepatology Research:
Our clinical studies include virus hepatitis (HBV and HCV), nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma (HCC) and clinical management after liver transplantation. For example, we have recently reported that the donor genotype affected liver steatosis and steatohepatitis following living-donor liver transplantation. We also showed the clinical characteristics of non-B non-C HCC.
We perform basic researches including the pathogenesis of HCC, viral hepatitis, NASH and its molecular mechanisms. For example, we have recently showed that exosomes secreted from senescence cell, affected the proliferation of HCC cell line. We also have found the roles of micro RNA in patients with chronic hepatitis C, NASH and HCV/HIV co-infection. We also investigated that Toyocamycin which attenuate the activation of XBP-1, attenuates hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates mouse model.