業績|長崎大学医学部 生化学教室

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業績

教授  伊藤敬

  • Endoh, M., Endo, T.A., Endoh, T., Isono, K., Sharif, J., Ohara, O., Toyoda, T., Ito, T.., Eskeland, R., Bickmore, W.A., Vidal, M., Bernstein, B.E., and Koseki, H. (2012). Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity. PLoS Genet 8, e1002774.  
  • Whitcomb, S.J., Fierz, B., McGinty, R.K., Holt, M., Ito, T., Muir, T.W., and Allis, C.D. (2012). Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Cross-talk with Histone Methyltransferases Dot1L and PRC2. J Biol Chem 287, 23718-23725.
  • Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, T., Ma, Y., Chua, K.J., Kubo, Y., Aihara, H., , Ito, T Nagayasu T, Matsuyama T, Hayashi H. (2011). Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel. Cytokine 56, 564-572.
  • Katoh Y, Ikura T, Hoshikawa Y, Tashiro S, Ito T, Ohta M, Kera Y, Noda T, Igarashi K. 2011. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein. Mol Cell 41: 554-566. 
  • Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L. 2010. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature 468: 1124-1128. 
  • Lancaster OM, Breuer M, Cullen CF, Ito T, Ohkura H. 2010. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila. PLoS Genet 6: e1001179. 
  • Higashi M, Inoue S, Ito T. 2010. Core histone H2A ubiquitylation and transcriptional regulation. Exp Cell Res 316: 2707-2712.  2009 JCR IF 3.589
  • Nakagawa, T., Kajitani, T., Togo, S., Masuko, N., Ohdan, H., Hishikawa, Y., Koji, T., Matsuyama, T., Ikura, T., Muramatsu, M., and Ito, T. 2008. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Genes Dev 22(1): 37-49.
  • Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K., and Kamiya, K. 2007. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol 27(20): 7028-7040.
  • Brittle, A.L., Nanba, Y., Ito, T., and Ohkura, H. 2007. Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation. Exp Cell Res 313(13): 2780-2785. 
  • Ito, T. 2007. Role of histone modification in chromatin dynamics. J Biochem (Tokyo) 141(5): 609-614.
  • Oki, M., Aihara, H., and Ito, T. (2007). Role of histone phosphorylation in chromatin dynamics and its implications in diseases. Subcell Biochem 41, 319-336.
  • Ito, K., Nakajima, Y., Onohara, Y., Takeo, M., Nakashima, K., Matsubara, F., Ito, T., and Yoshimoto, T. 2006. Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition. J Biol Chem 281(44): 33664-33676. 
  • Jin, C., Kato, K., Chimura, T., Yamasaki, T., Nakade, K., Murata, T., Li, H., Pan, J., Zhao, M., Sun, K., Chiu, R., Ito, T., Nagata, K., Horikoshi, M., and Yokoyama, K.K. 2006. Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nature Structural & Molecular Biology13(4): 331-338.  
  • Ito, K., Nakajima, Y., Xu, Y., Yamada, N., Onohara, Y., Ito, T., Matsubara, F., Kabashima, T., Nakayama, K., and Yoshimoto, T. 2006. Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis. J Mol Biol 362(2): 228-240.
  • Cullen, C.F., A.L. Brittle, T. Ito, and H. Ohkura. 2005. The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. J Cell Biol 171: 593-602. 
  • Furumatsu, T., M. Tsuda, K. Yoshida, N. Taniguchi, T. Ito, M. Hashimoto, and H. Asahara. 2005. Sox9 and p300 Cooperatively Regulate Chromatin-mediated Transcription. J Biol Chem 280: 35203-8.
  • Ivanovska, I., T. Khandan, T. Ito, and T.L. Orr-Weaver. 2005. A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev 19: 2571-82. 
  • Saeki, H., K. Ohsumi, H. Aihara, T. Ito, S. Hirose, K. Ura, and Y. Kaneda. (2005) Linker histone variants control chromatin dynamics during early embryogenesis. Proc Natl Acad Sci U S A 102: 5697-702. 
  • Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M. and Ito, T. (2004) Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev, 18, 877-888. 
  • Furukawa, H., Doh-Ura, K., Okuwaki, R., Shirabe, S., Yamamoto, K., Udono, H., Ito, T., Katamine, S. and Niwa, M. (2004) A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in Urine: CONTAMINATION WITH BACTERIAL OUTER MEMBRANE PROTEINS. J Biol Chem, 279, 23661-23667.
  • Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M. and Ito, T. (2004) Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun, 317, 259-264.
  • Mori, M., Yoneyama, M., Ito, T., Takahashi, K., Inagaki, F., and Fujita, T. (2004) Identification of ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem 279: 9698-9702.
  • Ito, T. 2003. Nucleosome assembly and remodeling. Curr Top Microbiol Immunol
    274: 1-22.
  • Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T.equalcorresponding, and Montminy, M. equalcorresponding(2002) Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol 22: 2974-2983. 
  • Ura, K., Araki, M., Saeki, H., Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda, Y., and Hanaoka, F. (2001) ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes. Embo J 20: 2004-2014.
  • Manning, E.T., Ikehara, T., Ito, T., Kadonaga, J.T., and Kraus, W.L. (2001) p300 Forms a stable, template-committed complex with chromatin: role for the bromodomain. Mol Cell Biol 21: 3876-3887.
  • Nakagawa, T., Bulger, M., Muramatsu, M., and Ito, T. (2001) Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor. J Biol Chem 276: 27384-27391.
  • Ito, T., Ikehara, T., Nakagawa, T., Kraus, W.L., and Muramatsu, M. (2000) p300-Mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev 14: 1899-1907.
  • Ito, T., Levenstein, M.E., Fyodorov, D.V., Kutach, A.K., Kobayashi, R., and Kadonaga, J.T. (1999) ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev 13: 1529-1539.
  • Mizuno, T., Nagamura H., Iwamoto, K. S., Ito, T., Fukuhara T., Tokunaga
     M.,Tokuoka S., Mabuchi K., and  Seyama, T. (1998) RNA from decades-old archival tissue blocks for retrospective studies. Diagnostic Molecular Pathology7:202-208,
  • Ito, T., Tyler, J.K., and Kadonaga, J.T. (1997) Chromatin assembly factors: a dual function in nucleosome formation and mobilization? Genes Cells 2: 593-600.
  • Ito, T., Bulger, M., Pazin, M.J., Kobayashi, R., and Kadonaga, J.T. (1997) ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90: 145-155.
  • Ito, T., Tyler, J.K., Bulger, M., Kobayashi, R., and Kadonaga, J.T. (1996) ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem 271: 25041-25048.
  • Ito, T., Bulger, M., Kobayashi, R., and Kadonaga, J.T. (1996) Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays. Mol Cell Biol 16: 3112-3124.
  • Iwamoto, K. S., Mizuno, T., Ito, T., Tsuyama, N., Kyoizumi, S., and Seyama, T. (1996) Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X irradiation, independently of the cell cycle and cell survival. Cancer Res. 56: 3862-3865.
  • Ito,T., Jessica, K. T., Bulger,M., Kobayashi,R., and Kadonaga,J.T. Structure and analysis of a nucleoplasmin-like protein from Drosophila melanogaster. J. Biol. Chem. 271:25041-25048, 1996.
  • Iwamoto, K. S., Mizuno, T., Ito, T., Akiyama, M. Takeichi, N., Mabuchi, K., and  Seyama, T. Feasibility of using decades-old archival tissues in molecular oncology/epidemiology.  American J. Pathology 149: 399-406, 1996.
  • Bulger, M., Ito, T., Kamakaka, R.T., and Kadonaga, J.T. 1995. Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein. Proc Natl Acad Sci U S A 92: 11726-11730.
  • Ito, T., Seyama.,T., Kyoizumi,S., Teraoka S., Iwamoto K.S., Mizuno T., Tsuyama N., Asahara T., Dohi K., Akiyama M. The usefulness of severe combined immunodeficiency(SCID) mice to study human carcinogenesis. Cancer Letters Vol88: 113 -117, 1995.
  • Ito,T., Seyama,T., Iwamoto,K.S., Mizuno T., Tronko N.D., Komissarenko I.V., Cherstovoy  E.D.,  Satow Y., Takeichi N., Dohi K., and Akiyama M. Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident. Lancet Vol344: 259, 1994.
  • Ito,T., Seyama,T., Hayashi, Y., Hayashi, T., Dohi, K., Mizuno, T., Iwamoto,K.S., Tsuyama, N., Nakamura, N., Akiyama, M.  Establishment of two human thyroid carcinoma cell lines(8305C, 8505C) bearing p53 gene mutations. Int. Journal Oncology 4: 583-586, 1994.
  • Ito, T., Seyama, T., Hayashi, T., Mizuno, T., Iwamoto, K. S.,  Tsuyama, N., Dohi, K., Nakamura, N.,  Akiyama, M. HaeIII polymorphism in intron 1 of the human p53 gene.  Human Genetics Vol93: 222, 1994.
  • Ito M., Mishima H.,  Inai K., Ito T., and Akiyama M. p53 and Rb tumor suppressor gene alterations in retinoblastoma. International Journal Oncology 4:1329-1332, 1994.
  • Ito,T., Seyama,T., Iwamoto,K.S., Hayashi, T., Mizuno, T., Tsuyama, N., Dohi, K., Nakamura, N., and Mitoshi, A. In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res. Vol53: 2940-2943, 1993.
  • Ito,T., Seyama,T., Mizuno,T.,  Iwamoto,K.S., Tsuyama, N., Hayashi, Y., Dohi, K., Nakamura, N., and Mitoshi, A. Genetic alterations in thyroid tumor
    progression: Association with p53 gene mutations. Jpn. J. Cancer Res. Vol84: 526-531, 1993.
  • Ito,T., Seyama,T., Mizuno,T., Hayashi, T., Iwamoto,K.S., Dohi, K., Nakamura, N., and Mitoshi, A. Induction of BCR-ABL fusion genes by in vitro X-irradiation. Jpn. J.Cancer Res. Vol84:105-109, 1993.
  • Hayashi, T., Seyama, T., Ito, T., Kusunoki, Y., Hirai, Y., Nakamura, N., and Akiyama, M. A simple and rapid method for HLA-DQA1 genotyping by polymerase chain reaction-single strand conformation polymorphism and restriction enzyme cleavage analysis. Electrophoresis, 13: 877-879, 1992.
  • Seyama, T., Ito, T., Hayashi, T., Mizuno, T., Nakamura, N., and Akiyama, M. A novel blocker-PCR method for detection of rare mutant alleles in the presence of an excess amount of normal DNA. Nucleic Acids Res., 20: 2493-2496, 1992.
  • Ito,T., Seyama,T., Mizuno,T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Nakamura, N., and Mitoshi, A. Unique association of p53 mutations with undifferentiated but not with differentiated carcinoma of the thyroid gland. Cancer Res. Vol52: 1369-1371, 1992.

(文責;長崎大学医学部生化学 教授 伊藤敬)

助教  中川武弥

  • Richly, H., Rocha-Viegas, L., Ribeiro, J.D., Demajo, S., Gundem, G., Lopez-Bigas, N., Nakagawa, T., Rospert, S., Ito, T., and Di Croce, L. (2010). Transcriptional activation of polycomb-repressed genes by ZRF1. Nature 468, 1124-1128.
  • Nakagawa, T., Kajitani, T., Togo, S., Masuko, N., Ohdan, H., Hishikawa, Y., Koji, T., Matsuyama, T., Ikura, T., Muramatsu, M., and Ito, T. (2008). Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Genes Dev 22, 37-49.
  • Nakagawa, T., Bulger, M., Muramatsu, M., and Ito, T. (2001). Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor. J Biol Chem 276, 27384-27391.
  • Ito, T., Ikehara, T., Nakagawa, T., Kraus, W.L., and Muramatsu, M. (2000). p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev 14, 1899-1907.
  • Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., and Ito, T. (2004). Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun 317, 259-264.
  • Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., and Montminy, M. (2002). Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol 22, 2974-2983.
  • Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., and Ito, T. (2004). Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev 18, 877-888.

(文責;長崎大学医学部生化学 助教 中川武弥、教授 伊藤敬)

助教  相原仁

  • Aihara H, Katikala L, Zeller RW, Di Gregorio A, Nibu Y.
    Optimization of a Method for Chromatin Immunoprecipitation Assays in the Marine Invertebrate Chordate Ciona. Mar Biotechnol (NY). 2013
  • Nowak SJ, Aihara H, Gonzalez K, Nibu Y, Baylies MK.
    Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis. PLoS Genet. 2012;8(3):e1002547. doi:
    10.1371/journal.pgen.1002547.
  • Shindo H, Yasui K, Yamamoto K, Honma K, Yui K, Kohno T, Ma Y, Chua KJ, Kubo Y, Aihara H, Ito T, Nagayasu T, Matsuyama T, Hayashi H.
    Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
    Cytokine. 56, 564-72. 2011
  • Stern MD, Aihara H, Roccaro GA, Cheung L, Zhang H, Negeri D, Nibu Y.
    CtBP is required for proper development of peripheral nervous system in Drosophila.
    Mech Dev
    . 126, 68-79, 2009.
  • Qi D, Bergman M, Aihara H, Nibu Y, Mannervik M.
    Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J. 27(6), 898-909, 2008.
  • Stern MD, Aihara H, Cho KH, Kim GT, Horiguchi G, Roccaro GA, Guevara E, Sun HH, Negeri D, Tsukaya H, Nibu Y.
    Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP. Dev Genes Evol. 217(11-12), 759-69, 2007.
  • Lilja T, Aihara H, Stabell M, Nibu Y, Mannervik M.
    The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo. Dev Biol. 305(2), 650-8, 2007.
  • Saeki H, Ohsumi K, Aihara H, Ito T, Hirose S, Ura K, Kaneda Y
    Linker histone variants control chromatin dynamics during early embryogenesis.
    Proc Natl Acad Sci U S A. 102(16), 5697-702, 2005.
  • Aihara H, Nakagawa T, Yasui K, Ohta T, Hirose S, Dhomae N, Takio K, Kaneko M, Takeshima Y, Muramatsu M, Ito T.
    Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev. 18(8), 877-88, 2004.
  • Hong T, Nakagawa T, Pan W, Kim MY, Kraus WL, Ikehara T, Yasui K, Aihara H, Takebe M, Muramatsu M, Ito T.
    Isoflavones stimulate estrogen receptor-mediated core histone acetylation.
    Biochem Biophys Res Commun. 317(1), 259-64, 2004.

(文責;長崎大学医学部生化学 助教 相原 仁、教授 伊藤 敬)

助教  水崎博文

  • Polanco, J.C., Wilhelm, D., Mizusaki, H., Jackson, A., Browne, C., Davidson, T., Harley, V., Sinclair, A., and Koopman, P. (2009). Functional analysis of the SRY-KRAB interaction in mouse sex determination. Biol Cell 101, 55-67.
  • Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K., and Katoh-Fukui, Y. (2008). Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature. Mol Reprod Dev 75, 1361-1371.
  • Wilhelm, D., Hiramatsu, R., Mizusaki, H., Widjaja, L., Combes, A.N., Kanai, Y., and Koopman, P. (2007). SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem 282, 10553-10560.
  • Wilhelm, D., Martinson, F., Bradford, S., Wilson, M.J., Combes, A.N., Beverdam, A., Bowles, J., Mizusaki, H., and Koopman, P. (2005). Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287, 111-124.
  • Matsuyama, M., Mizusaki, H., Shimono, A., Mukai, T., Okumura, K., Abe, K., Shimada, K., and Morohashi, K. (2005). A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells 10, 421-434.
  • Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, KI., Yamamoto, H., Kikuchi, A., and Morohashi, K. (2004). Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol 18, 2451-2462.
  • Mitsunaga, K., Araki, K., Mizusaki, H., Morohashi, K., Haruna, K., Nakagata, N., Giguère, V., Yamamura, K., and Abe, K. (2004). Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech Dev 121, 237-246.
  • Mizusaki, H., Kawabe, K., Mukai, T., Ariyoshi, E., Kasahara, M., Yoshioka, H., Swain, A., and Morohashi, K. (2003). Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad. Mol Endocrinol 17, 507-519.

(文責;長崎大学医学部生化学 助教 水崎博文、教授 伊藤敬)

研究員

研究員 池原強

  • Kuba-Miyara, M., Agarie, K., Sakima, R., Imamura, S., Tsuha, K., Yasumoto, T., Gima, S., Matsuzaki, G., and Ikehara, T. (2012). Inhibitory effects of an ellagic acid glucoside, okicamelliaside, on antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. International immunopharmacology 12, 675-681.
  • Ikehara, T., Imamura, S., Yoshino, A., and Yasumoto, T. (2010). PP2A Inhibition Assay Using Recombinant Enzyme for Rapid Detection of Okadaic Acid and Its Analogs in Shellfish. Toxins 2, 195-204.
  • Ikehara, T., Imamura, S., Sano, T., Nakashima, J., Kuniyoshi, K., Oshiro, N., Yoshimoto, M., and Yasumoto, T. (2009). The effect of structural variation in 21 microcystins on their inhibition of PP2A and the effect of replacing cys269 with glycine. Toxicon : official journal of the International Society on Toxinology 54, 539-544.
  • Ikehara, T., Imamura, S., Oshiro, N., Ikehara, S., Shinjo, F., and Yasumoto, T. (2008). A protein phosphatase 2A (PP2A) inhibition assay using a recombinant enzyme for rapid detection of microcystins. Toxicon : official journal of the International Society on Toxinology 51, 1368-1373.
  • Manning, E.T., Ikehara, T., Ito, T., Kadonaga, J.T., and Kraus, W.L. (2001). p300 Forms a stable, template-committed complex with chromatin: role for the bromodomain. Mol Cell Biol 21, 3876-3887.
  • Ito, T., Ikehara, T., Nakagawa, T., Kraus, W.L., and Muramatsu, M. (2000). p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev 14, 1899-1907.
  • Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., and Ito, T. (2004). Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun 317, 259-264.
  • Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., and Montminy, M. (2002). Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol 22, 2974-2983.

研究員 土井口真康

  • Iida H., Doiguchi M., Yamashita H., Sugimachi S., Ichinose J., Mori T., and Shibata Y. (2001). Spermatid-specific expression of Iba1, an ionized calcium binding adapter molecule-1, in rat testis. Biol Reprod. 64, 1138-1146.
  • Doiguchi M., Yamashita H., Ichinose J., Mori T., Shibata Y., and Iida H. (2002). Complementary DNA cloning and characterization of rat spergen-1, a spermatogenic cell-specific gene-1, containing a mitochondria-targeting signal. Biol Reprod. 66, 1462-1470.
  • Doiguchi M., Mori T., Toshimori K., Shibata Y., and Iida H. (2002). Spergen-1 might be an adhesive molecule associated with mitochondria in the middle piece of spermatozoa. Dev Biol. 252, 127-137.
  • Iida H., Urasoko A., Doiguchi M., Mōri T., Toshimori K., and Shibata Y. (2003). Complementary DNA cloning and characterization of rat spergen-2, a spermatogenic cell-specific gene 2 encoding a 56-kilodalton nuclear protein bearing ankyrin repeat motifs. Biol Reprod. 69, 421-429.
  • Iida H., Maehara K., Doiguchi M., Mōri T., and Yamada F. (2003). Bisphenol A-induced apoptosis of cultured rat Sertoli cells. Reprod Toxicol. 17, 457-464.
  • Iida H., Yamashita H., Doiguchi M., and Kaneko T. (2004). Molecular cloning of rat Spergen-3, a spermatogenic cell-specific gene-3, encoding a novel 75-kDa protein bearing EF-hand motifs. J Androl. 25, 885-892.
  • Iida H., Noda M., Kaneko T., Doiguchi M., and Mōri T. (2005). Identification of rab12 as a vesicle-associated small GTPase highly expressed in Sertoli cells of rat testis. Mol Reprod Dev. 71, 178-185.
  • Matsuyama T., Honda Y., Doiguchi M., and Iida H. (2005). Molecular cloning of a new member of TEKTIN family, Tektin4, located to the flagella of rat spermatozoa. Mol Reprod Dev. 72, 120-128.
  • Doiguchi M., Kaneko T., Urasoko A., Nishitani H., and Iida H. (2007). Identification of a heat-shock protein Hsp40, DjB1, as an acrosome- and a tail-associated component in rodent spermatozoa. Mol Reprod Dev. 74, 223-232.

(文責;長崎大学医学部生化学 教授 伊藤敬)

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