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細胞機能解析支援部門
担当:山本 一男 (准教授)
電話: 095-819-7188
Fax: 095-819-7093

Division of Cell Function Research Support
Head : Kazuo Yamamoto
    (Associate Professor)
Phone: +81-95-819-7188
Fax: +81-95-819-7093
e-mailkyamamot@nagasaki-u.ac.jp
  • 長崎大学医学部共同利用研究センター
研究業績 (Publication)
2017
  • Bayarsaikhan, G., Miyakoda, M., Yamamoto, K., Kimura, D., Akbari, M., Yuda, M., and Yui, K.
    Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei.
    Parasitology International 66 (3): 227-235 (2017)

  • Yamamoto, K., and Mak, T.W.
    Mechanicstic aspects of mammalian cell size control.
    Development, Growth & Differentiation 59 (1): 33-40 (2017)
2016
  • Ichinose, K., Ushigusa, T., Nishino, A., Nakashima, Y., Suzuki, T., Horai, Y., Koga, T., Kawashiri, S.Y., Iwamoto, N., Tamai, M., Arima, K., Nakamura, H., Obata, Y., Yamamoto, K., Origuchi, T., Nishino, T., Kawakami, A., and Tsokos, G.C.
    Lupus nephritis IgG induces the expression of calcium/calmodulin-dependent kinase type IV in podocytes and alters their function.
    Arthritis & Rheumatology 68 (4): 944-952 (2016)
2015
  • Itsumi, M., Inoue, S., Elia, A.J., Murakami, K., Sasaki, M., Lind, E.F., Brenner, D., Harris, I.S., Chio, I.I., Afzal, S., Cairns, R.A., Cescon, D.W., Elford, A.R., Ye, J., Lang, P.A., Li, W.Y., Wakeham, A., Duncan, G.S., Haight, J., You-Ten, A., Snow, B., Yamamoto, K., Ohashi, P.S., and Mak, T.W.
    Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio.
    Cell Death & Differentiation 22 (11): 1837-1845 (2015)

  • Harris, I.S., Trelor, A.E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K.C., Yung, K.Y., Knobbe-Thomsen, C.B., Brenner, D., Cox, M.A., Elia, A., Thorsten, B., Cescon, D.W., Adeoye, A., Brüstle1, A., Molyneux, S.D., Mason, J.M., Blaser, H., Li, W.Y., Yamamoto, K., Wakeham, A., Berman, H.K., Khokha, R., Done, S., Kavanagh, T.J., Lam, C.W., and Mak, T.W.
    Glutathione and thioredoxin antioxidant pathway synergize to drive cancer initiation and progression.
    Cancer Cell 27 (2): 211-222 (2015)
2014
  • Yamamoto, K., Gandin, V., Sasaki, M., McCracken, S., Li, W., Silvester, J.L., Elia, A.J., Wang, F., Wakutani, Y., Alexandrova, R., Oo, Y.D., Mullen, P.J., Inoue, S., Itsumi, M., Lapin, V., Haight, J., Wakeham, A., Shahinian, A., Ikura, M., Topisirovic, I., Sonenberg, N., and Mak, T.W.
    Largen: a molecular regulator of mammalian cell size control.
    Molecular Cell 53 (6): 904-915 (2014)
2013
  • Inoue, S., Hao, Z., Elia, A.J., Cescon, D., Zhou, L., Silvester, J., Snow, B., Harris, I.S., Sasaki, M., Li, W.Y., Itsumi, M., Yamamoto, K., Ueda, T., Dominguez-Brauer, C., Gorrini, C., Chio, II., Haight, J., You-Ten, A., McCracken, S., Wakeham, A., Ghazarian, D., Penn, L.J., Melino, G., and Mak, T.W.
    Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
    Genes & Development 27 (10): 1101-1114 (2013)

2012
  • Sasaki, M., Knobbe, C.B., Itsumi, M., Elia, A.J., Harris, I.S., Chio, I.I., Cairns, R.A., McCracken, S., Wakeham, A., Haight, J., Ten, A.Y., Snow, B., Ueda, T., Inoue, S., Yamamoto, K., Ko, M., Rao, A., Yen, K.E., Su, S.M., and Mak, T.W.
    D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
    Genes & Development 26 (18): 2038-2049 (2012)

  • Wang, F., Marshall, C. B., Yamamoto, K., Li, G.-Y., Gasmi-Seabrook, G. M., Okada, H., Mak, T. W., and Ikura, M.
    Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
    Proceedings of the National Academy of Sciences of the United States of America 109 (16): 6078-6083 (2012)

  • Zhang, Y., Xing, Y., Zhang, L., Mei, Y., Yamamoto, K., Mak, T. W., and You, H.
    Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.
    Proceedings of the National Academy of Sciences of the United States of America 109 (15): 5717-5722 (2012)
2011
  • Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, T., Ma, Y., Chua, K.J., Kubo, Y., Aihara, H., Ito, T., Nagayasu, T., Matsuyama, T., and Hayashi, H.
    Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
    Cytokine 56 (3): 564-572 (2011)

  • Hayashi, H., Kohno, T., Yasui, K., Murota, H., Kimura, T., Duncan, G. S., Nakashima, T., Yamamoto, K., Katayama, I., Ma, Y., Chua, K. J., Suematsu, T., Shimokawa, I., Akira, S., Kubo, Y., Mak, T. W., and Matsuyama, T.
    Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen 5 gene transcription.
    Proceedings of the National Academy of Sciences of the United States of America 108 (46): 18766-18771 (2011)

  • Su, Y. W., Hao, Z., Hirao, A., Yamamoto, K., Lin, W. J., Young, A., Duncan, G. S., Yoshida, H., Wakeham, A., Lang, P. A., Murakami, K., Hermeking, H., Vogelstein, B., Ohashi, P., and Mak, T. W.
    14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1.
    Proceedings of the National Academy of Sciences of the United States of America 108 (4): 1555-1560 (2011)
2009
  • Wang, F., Marshall, C. B., Li, G.-Y., Yamamoto, K., Mak, T. W., and Ikura, M.
    Synergistic interplay between promoter recognition and CBP/p300 coactivator recruitment by FOXO3a.
    ACS Chemical Biology 4 (12): 1017-1027 (2009)

  • Mei, Y., Zhang, Y., Yamamoto, K., Xie, W., Mak, T. W., and You, H.
    FOXO3a-dependent regulation of Pink1 mediates survival signaling in response to cytokine deprivation.
    Proceedings of the National Academy of Sciences of the United States of America 106 (13): 5153-5158 (2009)
2008
  • Wang, F., Marshall, C. B., Yamamoto, K., Li, G.-Y., Plevin, M. J., You, H., Mak, T. W., and Ikura, M.
    Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
    Journal of Molecular Biology 384 (3): 590-603 (2008)

  • Chen, N. J., Chio, I. I., Lin, W. J., Duncan, G., Chau, H., Katz, D., Huang, H. L., Pike, K. A., Hao, Z., Su, Y. W., Yamamoto, K., de Pooter, R. F., Zúñiga-Pflücker, J. C., Wakeham, A., Yeh, W. C., and Mak, T. W.
    Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
    Proceedings of the National Academy of Sciences of the United States of America 105 (34): 12429-12434 (2008)

  • Ushijima, R., Matsuyama, T., Nagata, I., and Yamamoto, K.
    Nucleolar targeting of proteins by the tandem array of basic amino acid stretches identified in the RNA polymerase I-associated factor PAF49.
    Biochemical and Biophysical Research Communications 369 (4): 1017-1021 (2008)
2007
  • Bakker, W. J., van Dijk, T. B., Parren-van Amelsvoort, M., Kolbus, A., Yamamoto, K., Steinlein, P., Verhaak, R. G., Mak, T. W., Beug, H., Lowenberg, B., and von Lindern, M.
    Differential regulation of Foxo3a target genes in erythropoiesis.
    Molecular and Cellular Biology 27 (10): 3839-3854 (2007)
2006
  • You, H., Pellegrini, M., Tsuchihara, K., Yamamoto, K., Hacker, G., Erlacher, M., Villunger, A., and Mak, T. W.
    FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
    The Journal of Experimental Medicine 203 (7): 1657-1653 (2006)

  • You, H., Yamamoto, K., and Mak, T. W.
    Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a.
    Proceedings of the National Academy of Sciences of the United States of America 103 (24): 9051-9056 (2006)
2005
  • Yoshida, K., Yamamoto, K., Kohno, T., Hironaka, N., Yasui, K., Kojima, C., Mukae, H., Kadota, J., Suzuki, S., Honma, K., Kohno, S., and Matsuyama, T.
    Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4.
    International Immunology 17 (11): 1463-1467 (2005)

  • Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., and Yui, K.
    Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS.
    Proceedings of the National Academy of Sciences of the United States of America 102 (44): 16001-16006 (2005)

  • Obata, Y., Yamamoto, K., Miyazaki, M., Shimotohno, K., Kohno, S., and Matsuyama, T.
    Role of cyclophilin B in activation of interferon regulatory factor-3.
    Journal of Biological Chemistry 280 (18): 18355-18360 (2005) 
2004
  • Nishiya, N., Yamamoto, K., Imaizumi, Y., Kohno, T., and Matsuyama, T.
    Identification of a novel GC-rich binding protein that binds to an indispensable element for constitutive IRF-4 promoter activity in B cells.
    Molecular Immunology 41 (9): 855-861 (2004)

  • Yamamoto, K., Yamamoto, M., Hanada, K., Nogi, Y., Matsuyama, T., and Muramatsu, M.
    Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.
    Molecular and Cellular Biology 24 (14): 6338-6349 (2004)

  • Suzuki, S., Honma, K., Matsuyama, T., Suzuki, K., Toriyama, K., Akitoyo, I., Yamamoto, K., Suematsu, T., Nakamura, M., Yui, K., and Kumatori, A.
    Critical roles of interferon regulatory factor 4 in CD11bhighCD8α- dendritic cell development.
    Proceedings of the National Academy of Sciences of the United States of America 101 (24): 8981-8986 (2004)

  • Furukawa, H., Doh-ura, K., Okuwaki, R., Shirabe, S., Yamamoto, K., Udono, H., Ito, T., Katamine, S., and Niwa, M.
    A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine: Contamination with bacterial outer membrane proteins.
    Journal of Biological Chemistry 279 (22): 23661-23667 (2004)

  • Nomura, M., Kobayashi, T., Kohno, T., Fujiwara, K., Tenno, T., Shirakawa, M., Ishizaki, I,, Yamamoto, K., Matsuyama, T., Mishima, M., and Kojima, C.
    Paramagnetic NMR study of Cu2+-IDA complex localization on a protein surface and its application to elucidate long distance information.
    FEBS Letters 566 (1-3): 157-161 (2004)
2003
  • Yamamoto, Y., Yamamoto, K., Yoshida, K., Kohno, T., Nogi, Y., and Matsuyama, T.
    IRF-1 and IRF-4 regulate target gene esxpression via interaction with DMP1.
    Acta Medica Nagasakiensia 48 (3-4): 167-174 (2003)

  • Murota, H., Hamasaki, Y., Nakashima, T., Yamamoto, K., Katayama, I., and Matsuyama, T.
    Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin fibroblasts.
    Arthritis & Rheumatism 48 (4): 1117-1125 (2003)

  • Imaizumi, Y., Murota, H., Kanda, S., Hishikawa, Y., Koji, T., Taguchi, T., Tanaka, Y., Yamada, Y., Ikeda, S., Kohno, T., Yamamoto, K., Mori, N., Tomonaga, M., and Matsuyama, T.
    Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia.
    Clinical Cancer Research 9 (1): 181-187 (2003)
2002
  • Sugita, S., Kohno, T., Yamamoto, K., Imaizumi, Y., Nakajima, H., Ishimaru, T., and Matsuyama, T.
    Induction of macrophage-inflammatory protein-3α gene expression by TNF-dependent NF-κB activation.
    The Journal of Immunology 168 (11): 5621-5628 (2002)

 

  • Imaizumi, Y., Sugita, S., Yamamoto, K., Imanishi, D., Kohno, T., Tomonaga, M., and Matsuyama, T.
    Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3α/CCL20 gene transcription via the NF-κB pathway.
    International Immunology 14 (2): 147-155 (2002)
2001
  • Nakamura, T., Kanda, S., Yamamoto, K., Kohno, T., Maeda, K., Matsuyama, T., and Kanetake, H.
    Increase in hepatocyte growth factor receptor tyrosine kinase activity in renal carcinoma cells is associated with increased motility partly through phosphoinositide 3-kinase activation.
    Oncogene 20 (52): 7610-7623 (2001)

  • Yamamoto, K., Yamamoto, M., Nogi, Y., and Muramatsu, M.
    Species-specific interaction of transcription factor p70 with the rDNA core promoter.
    Biochemical and Biophysical Research Communications 281 (4): 1001-1005 (2001)

  • Imazawa, Y., Imai, K., Yao, Y., Yamamoto, K., Hisatake, K., Muramatsu, M., and Nogi, Y.
    Isolation and characterization of the fission yeast gene Sprpa12+ reveals that the conserved C-terminal zinc-finger region is dispensable for the function of its product.
    Molecular and General Genetics 264 (6): 852-859 (2001)
2000
  • Imanishi, D., Yamamoto, K., Tsushima, H., Miyazaki, Y., Kuriyama, K., Tomonaga, M., and Matsuyama, T.
    Identification of a novel cytokine response element in the human IFN regulatory factor-1 gene promoter.
    The Journal of Immunology 165 (7): 3907-3916 (2000)

  • Yamamoto, K., Koga, A., Yamamoto, M., Nishi, Y., Tamura, T., Nogi, Y., and Muramatsu, M.
    Identification of a novel 70 kDa protein that binds to the core promoter element and is essential for ribosomal DNA transcription.
    Nucleic Acids Research 28 (5): 1199-1205 (2000)
1999
  • Makino, Y., Yogosawa, S., Kayukawa, K., Coin, F., Egly, J.-M., Wang, Z., Roeder, R. G., Yamamoto, K., Muramatsu, M., and Tamura, T.
    TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism.
    Molecular and Cellular Biology 19 (12): 7951-7960 (1999)

  • Imai, K., Imazawa, Y., Yao, Y., Yamamoto, K., Hisatake, K., Muramatsu, M., and Nogi, Y.
    The fission yeast rpa17+ gene encodes a functional homolog of AC19, a subunit of RNA polymerases I and III of Saccharomyces cerevisiae.
    Molecular and General Genetics 261 (2): 364-373 (1999)
1997
  • Kanemaki, M., Makino, Y., Yoshida, T., Kishimoto, T., Koga, A., Yamamoto, K., Yamamoto, M., Moncollin, V., Egly, J.-M., Muramatsu, M., and Tamura, T.
    Molecular cloning of a rat 49-kDa TBP-interacting protein that is highly homologous to the bacterial RuvB.
    Biochemical and Biophysical Research Communications 235 (1): 64-68 (1997)

  • Nishi, Y., Yamamoto, K., Yao, Y., Yamamoto, M., Nogi, Y., Matsuo, H., and Muramatsu, M.
    Isolation and characterization of cDNA encoding mouse RNA polymerase II subunit RPB14.
    Gene 187 (2): 165-170 (1997)

  • Korobko, I. V., Yamamoto, K., Nogi, Y., and Muramatsu, M.
    Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31.
    Gene 185 (1): 1-4 (1997)
1996
  • Yao, Y., Yamamoto, K., Nishi, Y., Nogi, Y., and Muramatsu, M.
    Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III.
    Journal of Biological Chemistry 271 (51): 32881-32885 (1996)

  • Hanada, K., Song, C. Z., Yamamoto, K., Yano, K., Maeda, Y., Yamaguchi, K., and Muramatsu, M.
    RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription.
    The EMBO Journal 15 (9): 2217-2226 (1996)
1994
  • Song, C. Z., Hanada, K., Yano, K., Maeda, Y., Yamamoto, K., and Muramatsu, M.
    High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40.
    Journal of Biological Chemistry 269 (43): 26976-26981 (1994)
1992
  • Yamamoto, K., Yee, C. C., Shirakawa, M., and Kyogoku, Y.
    Characterization of the bacterially expressed Drosophila engrailed homeodomain.
    Journal of Biochemistry 111 (6): 793-797 (1992)
1991
  • Yamamoto, K., Mori, S., Okamoto, T., Shimotohno, K., and Kyogoku, Y.
    Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1.
    Nucleic Acids Research 19 (22): 6107-6112 (1991)