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Molecular genetic
study of virulence factors in periodontal pathogen, Porphyromonas gingivalis. |
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The whole genome sequence of P. gingivalis ATCC
33277, which is the type strain of P. gingivalis and
has been widely used for characterization of pathophysiological
features of the microorganism, has been determined. (Naito M.
et al, DNA Res. 2008) The fully annotated genome sequence of P.
gingivalis strain ATCC 33277 has been deposited in GenBank/EMBL/DDBJ
databases under the accession number AP009380.
The whole genome sequence of ATCC 33277 is compared with that
of a virulent strain, W83. Although the genome size and GC content
are almost the same, extensive genome rearrangements are detected
between the two strains, many of which have been induced by
various mobile genetic elements (IS, MITE, Tn and CTn). Such
structural alterations of the P. gingivalis genomes
generate many strain-specific CDSs (protein-coding sequences),
which may be closely associated with difference in virulence
of the two strains. |
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Copyright© 2004-2008 Department of Molecular Microbiology
and Immunology,
Nagasaki University Graduate School of Biomedical Sciences All
Rights Reserved. |
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