口腔病原微生物学(歯学部細菌)
 
研究業績
2006 2005 2004 2003 2002 2001 2000
1999 1998 1997 1996 1995


2006
Naito, M., Sakai, E., Shi, Y., Ideguchi, H., Shoji, M., Ohara, N., Yamamoto, K., and Nakayama, K.: Porphyromonas gingivalis-induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinase. Mol. Microbiol. 59: 152-167, 2006.

Kishimoto, M., Yoshimura, A., Naito, M., Okamoto, K., Yamamoto, K., Golenbock, D. T., Hara, Y. and Nakayama, K.: Gingipains inactivates a cell surface ligand on Porphyromonas gingivalis that induces TLR2- and TLR4-independent signaling. Microbiol. Immunol. 50(4): 315-325, 2006

Matsuo, K., Hotokezaka, H., Ohara, N.,Fujimura, Y., Yoshimura, A., Okada, Y., Hara, Y., Yoshida, N. and Nakayama, K.: Analysis of amphotericin B-Induced cell signaling with chemical inhibitors of signaling molecules. Microbiol. Immunol. 50(4): 337-347, 2006.

Fujimura, Y., Hotokezaka, H., Ohara, N., Naito, M., Sakai, E., Yoshimura, M., Narita, Y., Kitaura, H., Yoshida, N. and Nakayama, K.: Hemoglobin receptor protein (HbR) of Porphyromonas gingivalis inhibits receptor activator NF-kB ligand-induced osteoclastogenesis from bone marrow macrophages. Infect. Immun. 74(5): 2544-2551, 2006.

Ohara, N., Kikuchi, Y., Shoji, M., Naito, M., and Nakayama, K.: Superoxide Dismutase-encoding gene of the obligate anaerobe Porphyromonas gingivalis is regulated by the redox-sensing transcription activator OxyR. Microbiology 152: 955-966, 2006.

Urnowey, S., Ansai, T., Bitko, V., Nakayama, K., Takehara, T., and Barik, S.: Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signalling. BMC Microbiol. 6:26, 2006.

Kitaura, H., Tatamiya, M., Nagata, N., Fujimura, Y., Eguchi, T., Yoshida, N., and Nakayama, K.: IL-18 induces apoptosis of adherent bone marrow cells in TNF-alpha mediated osteoclast formation in synergy with IL-12. Immunol. Lett. in press.

Ito, K., Nakajima, Y., Xu, Y., Yamada, N., Onohara, Y., Matsubara, F., Kabashima T., Nakayama, K., and Yoshimoto, T.: Crystal structure and mechanims of triprptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis. J. Mol. Biol. in press.

Kamijo K, Ohara N, Abe M, Uchiyama A, Hosoya H, Lee J-S, Miki T: Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol. Biol. Cell. 17(1): 43-55, 2006 (6.520)

Takahashi H, Sasaki K, Takahashi M, Shigenori N, Honda S, Arimitsu H, Ochi S, Ohara N, Tsuji T: Mutant Escherichia coli enterotoxin as a mucosal adjuvant causes specific CD4+ and CD8+ T cells to produce IFNg and TNFa in response to nasal killed-bacillus Catmette-Guerin vaccine in mice. Vaccine. 24(17): 3591-3598, 2006 (2.822)
 
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2005

Sato, K., Sakai, E., Veith, P.D., Shoji, M., Kikuchi, Y., Yukitake, H., Ohara, N., Naito, M., Okamoto, K., Reynolds, E.C., and Nakayama, K.: Identification of a new membrane-associated protein which influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis. J. Biol. Chem. 280(10): 8668-8677 (2005).

Kikuchi, Y., Ohara, N., Sato, K., Yoshimura, M., Yukitake, H., Sakai, E., Shoji, M., Naito, M., and Nakayama, K.: Novel stationary-phase-upregulated protein of Porphyromonas gingivalis influences the production of superoxide dismutase, thiol perxidase and thioredoxin. Microbiology, 151: 841-853 (2005).

Suketa, N., Sawase, T., Kitaura, H., Naito, M., Baba, K., Nakayama, K., Wennerberg, A., and Atsuta, M.: The antibacterial surface of dental implants based on the photocatalytic bactericidal effect. Clinical Implant Dentistry and Related Research. 7(2): 105-111 (2005).

Uehara, A., Muramoto, K., Imamura, T., Nakayama, K., Potempa, J., Travis, J., Sugawara, S., and Takada, H.: Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture. J. Immunol. 175: 6076-6084 (2005).

Kita Y, Tanaka T, Yoshida S, Ohara N, Kaneda Y, Kuwayama S, Muraki Y, Kanamaru N, Hashimoto S, Takai H, Okada C, Fukunaga Y, Sakaguchi Y, Furukawa I, Yamada K, Inoue Y, Takemoto Y, Naito M, Yamada T, Matsumoto M, McMurray DN, Cruz EC, Tan EV, Abalos RM, Burgos JA, Gelber R, Skeiky Y, Reed S, Sakatani M, Okada M. Novel recombinant BCG and DNA-vaccination against tuberculosis in a cynomolgus monkey model. Vaccine. 2005 Mar 18;23(17-18):2132-5.
 
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2004

Okamoto, M., Sugimoto, A., Leung, K. ミP., Nakayama, K., Kamaguchi, A., and Maeda, N.: Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis. Oral Microbiol. Immunol. 19: 118-120 (2004). (1.242)

Inaba, H., Kawai, S., Nakayama, K., Okahashi, N., and Amano, A. : Effect of enamel matrix derivative on periodontal ligament cells diminished by Porphyromonas gingivalis. J. Periodontol. 75(6):858-865 (2004). (1.490)

Okahashi, N., Inaba, H., Nakagawa, I., Yamamura, T., Kuboniwa, M., Nakayama, K., Hamada, S., and Amano, A. : Porphyromonas gingivalis induces receptor activator of NF-kB ligand expression on osteoblasts through activator protein-1 pathway. Infect. Immun. 72 (3): 1706-1714 (2004). (3.875)

Saito, K., Ohara, N., Hotokezaka, H., Fukumoto, S., Yuasa, K., Naito, M., Fujiwara, T., and Nakayama, K. : Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis. J. Biol. Chem. 279(14):13555-13563 (2004). (6.482)

Goulet, V., Britigan, B., Nakayama, K., and Grenier, D. : Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes the formation of hydroxyl radicals. Infect. Immun. 72(8):4351-4356 (2004). (3.875)

Shoji, M., Naito, M., Yukitake, H., Sato, K., Sakai, E., Ohara, N., and Nakayama, K. : The major structural components of two cell-surface filaments of Porphyromonas gingivalis are matured through lipoprotein precursors. Mol. Microbiol. 52(5):1513-1525 (2004). (5.563) 

Kamaguchi, A., Nakano, M., Shoji, M., Nakamura, R., Sagane, Y., Okamoto, M., Watanabe, T., Ohyama, T., Ohta, M., and Nakayama, K.: Autolysis of Porphyromonas gingivalis is accompnied by an increase in several periodontal pathogenic factors in the supernatant. Microbiol. Immunol. 48(7):541-545 (2004).(1.111)

Abe, N., Baba, A., Takii, R., Nakayama, K., Kamaguchi, A., Shibata, Y., Abiko, Y., Okamoto, K., Kadowaki, T., and Yamamoto, K.: Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA. Biol. Chem. 385: 1041-1047 (2004). (3.366)

Kawano T, Kobayakawa T, Fukuma Y, Yukitake H, Kikuchi Y, Shoji M, Nakayama K, Mizuno A, Takagi T, Nemoto TK.: A comprehensive study on the immunological reactivity of the Hsp90 molecular chaperone. J. Biochem, 136: 711-722 (2004) (2.148)

Miki K, Nagata T, Tanaka T, Ohara N, et al.: Induction of protective cellular immunity against Mycobacterium tuberculosis by recombinant attenuated self-destructing Listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPB/MPT51, Infect Immun, 72:2014-2021 (2004). (3.875)

Saito SI, Liu X-F, Kamijo K, Ohara N, et al.: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. J Biol Chem 279:7169-7179 (2004). (6.482)

Lee J-S, Kamijo K, Ohara N, Kitamura T, Miki T: MgcRacGAP regulates membrane blebbing through RhoA during cytokinesis. Exp Cell Res, 293:275-282 (2004). (3.949)

 
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2003

Ueshima J., Shoji M., Ratnayake D. B., Abe K., Yoshida S., Yamamoto K., and Nakayama K.: Dps from the obligate anaerobe Porphyromonas gingivalis: purification, gene cloning, gene expression and mutant studies. Infect. Immun. 71(3): 1170-1178, 2003. (4.039)

Kamaguchi A., Ohyama T., Sakai E., Nakamura R., Watanabe T., Baba H., and Nakayama K.: Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for coaggregation with Prevotella intermedia. Microbiology 149: 1257-1264, 2003. (2.897)

Kitaura H, Nagata N, Fujimura Y, Hotokezaka H, Tatamiya M, Nakao N., Yoshida N, and Nakayama K.: Interleukin-4 directly inhibits tumor necrosis factor-a-mediated osteoclast formation in mouse bone marrow macrophages. Immunol. Lett. 88(3): 193-198, 2003. (1.847)

Kamaguchi A., Nakayama K., Ichiyama S., Nakamura R., Watanabe T., Ohta M., Baba H., and Ohyama T.: Effect of Porphyromonas gingivalis Vesicles on Coaggregation of Staphylococcus aureus to Oral Microorganisms. Curr. Microbiol. 47: 485-491, 2003. (1.210)

Houle M-A., Grenier D., Plamondon P., and Nakayama K.: The collagenolytic activity of Porphyromonas gingivalis is due to its Arg-gingipain. FEMS Microbiol. Lett. 221(2): 181-185, 2003. (1.804)

Nagata N., Kitaura H., Yoshida N., and Nakayama K.: Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-g possibly induced from non-T cell population. Bone 33: 721-732, 2003. (3.755)

Grenier D., Roy S., Chandad F., Plamondon P., Yoshioka M., Nakayama K., and Mayrand D.: Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis. Infect. Immun. 71: 4742-4748, 2003. (4.039)

Review

Nakayama K.: Molecular Genetics of Porphyromonas gingivalis: gingipains and other virulence factors. Current Protein and Peptide Science 4: 389-395, 2003.

 
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2002

Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K., Kitaura, H., Yoshida, N. and Nakayama, K.: U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 277, 47366-47372, 2002. (7.258)

Kitaura, H., Nagata, N., Fujimura, Y., Hotokezaka, H., Yoshida, N. and Nakayama, K.: Effect of IL-12 on TNF-a-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas/Fas ligand interaction. J. Immunol. 169(9), 4732-4738, 2002. (7.065)

Shoji, M., Ratnayake, D.B., Shi, Y., Kadowaki, T., Yamamoto, K., Yoshimura, F., Akamine, A., Curtis, M.A. and Nakayama, K.: Construction and characterization of a nonpigmented mutant of Porphyromonas gingivalis: cell surface polysaccharide as an anchorage for gingipains. Microbiology 148, 1183-1191, 2002. (2.846)

Kitaura, H., Ohara, N., Nakao, N., Yoshida, N. and Yamada, T.: Changed activation of HIV-1 LTR in monocytoid cells by Mycobacteria with temporal progression of infection. Microbiologica, 25(3), 357-361, 2002. (0.692)

Ohara N., Ohara N., Yanagiguchi K., Yamada S., Viloria IL. and Hayashi Y.: Expression of alkaline phosphatase induces rapid and artificial minelization in specific transformed Escherichia coli. Microbiologica. 25, 107-110, 2002. (0.692)

Review

Yamamoto S., Yamamoto T., Nojima Y., Umemori K., Phalen S., McMurray DN., Kuramoto E., Iho S., Takanji R., Sato Y., Yamada T., Ohara N., Matsumoto S., Goto Y,, Matsuo K. and Tokunaga T.: Discovery of immunostimulatory CpG-DNA and its application to tuberculosis vaccine development. Jpn. J. Infect. Dis., 55, 37-44, 2002.

Book

Ohara, N., Tabira, Y., Ohara, N. and Yamada T.:(2001) Learning from bacteria: molecular chaperones in ribosomes and thermophilic adaptation. In Kosaka M, Sugawara T, Schmidt KL, Simon E. (eds) Thermotherapy in practice: Applications in Neoplasia, Inflammation, and Pain. Springer-Verlag Tokyo, Tokyo, Japan, pp. 346-354.

 
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2001

Grenier, D., Imbeault, S., Plamondon, P., Grenier, G., Nakayama, K. and Mayrand, D.: Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect. Immun., 69(8), 5166-5172, 2001. (4.204)

Kamaguchi, A., Nakayama, K., Ohoyama, T., Watanabe, T., Okamoto, M. and Baba, H. : Coaggregation of Porphyromonas gingivalis and Prevotella intermedia. Microbiol. Immunol., 44(9), 649-656, 2001. (1.070)

Chen, T., Nakayama, K., Belliveau, L. and Duncan, M.J.: Porphyromonas gingivalis gingipains and adhesion to epithelial cells. Infect. Immun., 69(5), 3048-3056, 2001. (4.204)

Grenier, D., Gauthier, P., Plamondon, P., Nakayama, K. and Mayrand, D.: Studies on the aminopeptidase activities of Porphyromonas gingivalis. Oral Microbiol. Immunol., 16(4), :212-217, 2001. (1.419)

Yoneda, M., Hirofuji, T., Anan, H., Matsumoto, A., Hamachi, T., Nakayama, K. and Maeda, K.: Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in a murine abscess model: Involvement of gingipains in a synergistic effect. J. Periodont. Res., 36, 237-243, 2001.(0.946)

Brochu, V., Grenier, D., Nakayama, K. and Mayrand, D.: Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg- and Lys-gingipain activities. Oral Microbiol. Immunol., 16(2), 79-87, 2001. (1.419)

Ohara, N., Matsuoka, M., Nomaguchi, H., Naito, M. and  Yamada ,T.: Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guein over-producing three putative protective antigen candidates. Vaccine, 19,1906-1910, 2001. (2.476)

Kitaura, H., Ohara, N., Kobayashi, H. and Yamada, T.: TNF-alpha-mediated multiplication of human immunodeficiency virus in chronically infected monocytoid cells by mycobacterial infection. APMIS, 109, 533-540, 2001. (1.713)

Kitaura, H., Ohara, N., Kobayashi, K. and Yamada, T.: TNF-alpha-mediated activation of HIV-1 LTR in monocytoid cells by mycobacteria. FEMS Immunol. Med. Microbiol., 31, 97-103, 2001.(1.244)

Furugen, M, Matsumoto, S., Matsuo, T., Matsumoto, M. and Yamada ,T.: Identification of the mycobacterial DNA-binding protein 1 region which suppresses transcription in vitro. Microb Pathog., 30(3), 129-38, 2001. (2.144)

Review


Ohara, N. and Yamada, T. : Recombinant BCG vaccines. Vaccine 19,4089-4090, 2001.(2.476)

Book

Ohara, N., Tabira, Y., Ohara, N. and Yamada T.:(2001) Learning from bacteria: molecular chaperones in ribosomes and thermophilic adaptation. In Kosaka M, Sugawara T, Schmidt KL, Simon E. (eds) Thermotherapy in practice: Applications in Neoplasia, Inflammation, and Pain. Springer-Verlag Tokyo, Tokyo, Japan, pp. 346-354.
 
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2000

Naito, M., Fukuda, T., Sekiguchi, K. and Yamada, T.:The domains of human fibronectin mediating the binding of a antigen, the most immunopotent antigen of mycobacteria that induces protective immunity against mycobacterial infection. Biochem. J., 347, 725-731, 2000.(4.349)

Matsumoto, S., Yukitake, H., Kanbara, K. and Yamada, T.:Long-lasting immunity against rodent malaria parasite infection at the blood stage by recombinant BCG secreting merozoite surface protein-1. Vaccine, 18, 832-834, 2000 (3.173)

Naito, M., Matsuoka, M., Ohara, N., Nomaguchi, H. and Yamada, T.:The antigen 85 complex veccine against experimental Mycobacterium leprae infection in mice. Vaccine, 18, 795-798, 2000 (3.173)

Adachi, N., Matsumoto, S., Tokuhisa, M., Kobayashi, K. and Yamada, T.:Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders. J. Dent. Res., 79, 1752-1757, 2000 (4.556)

Yamada, H., Matsumoto, S., Matsumoto, T., Yamada, T. and Yamashita, U.:Murine IL-2 secreting recombinant Bacillus Calmette-Guerin augments macrophage-mediated cytotoxicity against murine bladder cancer MBT-2. J. Urol., 164, 526-531, 2000 (2.486)

Matsumoto, S., Furugen, M., Yukitake, H. and Yamada, T.:The gene encoding mycobacterial DNA-binding protein I (MDPI) transformed rapidly growing bacteria to slowly growing bacteria. FEMS Microbiol. Lett., 182, 297-301, 2000 (1.673)

Ohara, N., Matsuoka, M., Nomaguchi, H., Naito, M. and Yamada, T. :Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by recombinant Bacillus Catmette- Guerin (BCG). Vaccine, 18, 1294-1297, 2000 (3.173)

Tabira, Y., Ohara, N. and Yamada, T. :Identification and characterization of the ribosome-associated protein, HrpA, of Bacillus Calmette Guerin. Microb. Pathog., 29, 213-222, 2000

Kitaura, H., Ohara, N., Naito, M., Kobayashi, K. and Yamada, T. :Fibronectin-binding proteins secreted by Mycobacterium avium. APMIS, 108, 558-564, 2000 (1.097)

 
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1999

Miyazaki, C., Ohara, N., Yukitake, H., Kinomoto, M., Matsushita, K., Matsumoto, S., Mizuno, A. and Yamada, T.: Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Gu屍in. Vaccine 17, 245-251, 1999. (2.234)

Kitaura, H., Ohara, N., Naito, M., Kobayashi, K. and Yamada, T.: Species-specific B-cell epitope on the C-terminal region of the alpha antigen from Mycobacterium intracellulare in mice. Vet. Microbiol. 65, 9-19, 1999. (1.137)

Tanagawa, M., Yoshida, K., Matsumoto, S., Yamada, T. and Atsuta, M.: Inhibitory effect of antibacterial resin composite against Streptococcus mutans. Caries Res. 33, 366-371, 1999. (1.283) 

Naito, M., Matsuoka, M., Ohara, N., Nomaguchi, H. and Yamada, T.: The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice. Vaccine 18, 795-798, 1999. (2.234)

Matsumoto, S., Yukitake, H., Kanbara, H. and Yamada, T.: Long-lasting protective immunity against rodent malaria parasite infection at the blood stage by recombinant BCG secreting merozoite surface protein-1. Vaccine 18, 832-834, 1999. (2.234) 

Kitaura, H., Kinomoto, M. and Yamada, T.: Ribosomal protein L7 included in tuberculin purified protein derivative (PPD) is a major heat-resistant protein inducing strong delayed-type hypersensitivity. Scand. J. Immunol. 50, 580-587, 1999. (1.781) 

Matsumoto, S., Yukitake, H., Furugen, M., Matsuo, T., Mineta, T. and Yamada, T.: Mycobacterium bovis bacillus Calmette-Guerin. Microbiol. Immunol. 43, 1027-1036, 1999. (0.940) 

 
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1998

Matsumoto, S., H. Yukitake, H. Kanbara, and T. Yamada. : Recombinant Mycobacterium bovis bacillus Calmette-Guerin secreting merozoite surface protein 1 (MSP1) induces protection against rodent malaria parasite infection depending on MSP1-stimulated interferon _ and parasite-specific antibodies. Journal of Experimental Medicine, 188, 845-854. 1998.

Naito, M., N. Ohara, S. Matsumoto, and T. Yamada. : The novel fibronectin-binding motif and key residues of mycobacteria. Journal of Biological Chemistry, 273, 2905-2909. 1998.

Matsumoto, S., H. Yukitake, N. Ohara, T. Dairi, H. Kanbara, and T. Yamada.: Shotgun cloning and characterization of the thymidylate synthase-encoding gene from Mycobacterium bovis BCG. Microbiology & Immunology, 42, 15-21, 1998.

Naito, M., S. Izumi, and T. Yamada. : Two-dimensional electrophoretic analysis of humoral responses to culture filtrate of Mycobacterium bovis BCG in patients with leprosy and tuberculosis. International Journal of Leprosy & Other Mycobacterial Diseases, 66, 208-213.1998.

Naito, M., N. Ohara, S. Matsumoto, and T. Yamada. : Immunological characterization of alpha antigen of Mycobacterium kansasii : B-cell epitope mapping. Scandinavian Journal of Immunology, 48, 73-78, 1998.

Tobiume, M., K. Fujinaga, M. Kameoka, T. Kimura, T. Nakaya, T. Yamada, and K. Ikuta. :  Dependence on host cell cycle for activation of human immunodeficiency virus type 1 gene expression from latency. Journal of General Virology, 79, 1363-1371, 1998.

Hayashida, H., H. Hotokezaka, N. Ohara, T. Koseki, T. Nishihara, O. Takagi, and T. Yamada. : Differentiation of clinical isolates of Actinobacillus actinomycetemcomitans using an insertion sequence, ISAa1. Oral Microbiology & Immunology, 13, 120-123. 1998.

Minami, J., S. Matsumoto, and T. Yamada. : Putative heat shock protein 70 gene from Actinobacillus actinomycetemcomitans: molecular cloning and sequence analysis of its gene. Oral Microbiology & Immunology, 13, 113-119. 1998.

Mineda, T., N. Ohara, H. Yukitake, and T. Yamada. : The ribosomes contents of mycobacteria.  Microbiologica  (Italy), 21, 1-8, 1998.

Hotokezaka, H., A. Kitamura, S. Matsumoto, S. Hanazawa, S. Amano, and T. Yamada. : Internalization of Mycobacterium bovis Bacillus Calmette-Gu_rin  into osteoblast-like MC3T3-E1 cells and bone resorptive responses of the cells against the infection. Scandinavian Journal of Immunology, 47, 453-458. 1998.

Tabira, Y., N. Ohara, H. Kitaura, S. Matsumoto, M. Naito, and T. Yamada. : The 16-kDa alpha-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is associated with ribosomes. Research in Microbiology, 149, 255-264, 1998.

Kitaura, H., N. Ohara, T. Matsuo, K. Kobayashi, and T. Yamada. : PCR amplification of 16S ribosomal RNA gene for detection of bacterial infection in root canal. Dentistry in Japan,  34, 21-23,  1998.

Kitaura, H., N. Ohara, M. Naito, K. Kobayashi, and T. Yamada. : Serological analysis of C-terminal region of alpha antigen from Mycobacterium avium-intracellulare complex and Mycobacterium tuberculosis. APMIS, 106, 893-900,  1998.

Kitaura, H., N. Ohara, M. Naito, K. Kobayashi, and T. Yamada. : Species-specific B cell epitope on the C-terminal region of the alpha antigen from Mycobacterium  intracellulare  in  mice. Veterinary Microbiology (Netherland), 106, 893-900,  1998.

 
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1997

Ohara N., N.Ohara-Wada, H.Kitaura, T.Nishiyama, S.Matsumoto and T.Yamada : Analysis of the genes encoding the Antigen 85 complex and MPT51 from Mycobacterium avium. Infect. Immun. 65:3680-3685, 1997.

Ohara N., T.Nishiyama, N.Ohara-Wada, S.Matsumoto, T.Matsuo and T.Yamada : Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG.  Microbial Pathogenesis 23:303-310, 1997.

Ohara N., N.Ohara, M.Naito, C.Miyazaki, S.Matsumoto, Y.Tabira and T.Yamada : HrpA, a new ribosome-associated protein, which appears in heat-stressed Mycobacterium bouvis Bacillus Calmette-Guerin.  J. Bacteriol. 179:6495-6498, 1997.

Kitaura H., N.Adachi, K.Kobayashi and T.Yamada : Knowledge and attitudes of Japanese dental health care workers towards HIV related disease. J. Dentistry .25:279-283, 1997.

Nakamura Y., M.Kameoka, M.Tobiume, M.Kaya, K.Ohki, T.Yamada and K.Ikuta : A chain section containing epitopes for cytotoxic T, B and helper T cells within a highly conserved region found in the human immunodeficiency virus type 1 Gag protein.  Vaccine 15:489-496, 1997.

Hayashida,H., H.Hotokezaka, N.Ohara, M.Kimura, O.Takagi and T.Yamada : Cloning and sequencing of part of S10 operon from Actinobacillus (Haemophilus) actinomycetemcomitans FDC Y4.  Oral Microbiology and Immunology  12:174-177, 1997.

Hotokezaka,H., N.Ohara, H.Hayashida, S.Matsumoto, T.Matsuo, M.Naito, K.Kobayashi, and T.Yamada : Transcriptional analysis of groESL from Porphyromonas gingivalis.  Oral Microbiology and Immunology 12:236-239, 1997.

Matsuoka,M., H.Nomaguchi, H.Yukitake, N.Ohara, S.Matsumoto, K.Mise and T.Yamada : Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by immunization with ribosomal fraction and culture filtrate from Mycobacterium bovis BCG. Vaccine 15:1214-1217, 1997.

Takano,M., N.Ohara, M.Naito, S.Matsumoto, T.Matsuo, R.Shirai, A.Mizuno and T.Yamada : Species-specific B-cell epitope on the C-terminal region of the α antigen from Mycobacterium scrofulaceum. Microbial Pathogenesis  23:95-100, 1997.

 
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1996

Matsumoto,S.,M.Tamaki,H.Yukitake,T.Matsuo,M.Naito,H.Teraoka and T. Yamada: A stable E.coli-mycobacteria shuttle vector "pSO246" in Mycobacterium bovis BCG. FEMS Microbiol. Lett. 135:237-243. 1996

Wada,N.,N.Ohara,M.Kameoka,Y.Nishino,S.Matsumoto,T.Nishiyama,M.Naito, H.Yukitake,Y.Okada,K.Ikuta and T.Yamada: Long-lasting immune response induced by recombinant Bacillus Calmette-Guerin(BCG) secretion system. Scandinavian J.Immunology 43:202-209. 1996

Matsuo,T.,H.Matsuo,N.Ohara,S.Matsumoto,H.Kitaura,A.Mizuno and T. Yamada: Cloning and sequencing of the MPB70 homologue corresponding to MPB 83 from Mycobacterium bovis BCG. Scandinavian J.Immunology 43:483-489 1996

Matsumoto,S.,T.Yanagi,H.Yukitake,N.Ohara,N.Wada,H.Kambara and T. Yamada: Stable expression and secretion of protective B-cell epitope of rodent malaria from Mycobacterium bovis BCG and induction oflong-lasting humoral response in mouse. Vaccine 14:54-60. 1996

Nomaguchi,H.,Y.Yogi,M.Matsuoka,Y.Fukutomi,H.Okamura,K.Nagata,S.Nagai N.Ohara and T.Yamada: BCG Vaccination to Mycobacterium leprae Infectionin mice. Jpn J.Leprosy 65:106-112. 1996

Hayashida,H.,H.Hotokezaka,N.Ohara,M.Kimura,O.Takagi and T.Yamada: Molecular analysis of new insertion sequence from Haemophilus actinomycetomcomitans FDC Y4. Microbiology(UK) 142:2449-2452.1996

 
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1995

Iwanaga, S., N. Ohara, T. Kariu, N. Yamasaki, M. Kimura and T. Yamada : Cloning and nucleotide sequence of the gene cluster encoding ribosomal proteins S12 and S7 from M.bovis BCG. Biochem. Mol. Biol. Internat. 36, 209-218, 1995.

Yanagiguchi, K., M. Kawaguchi, S. Egashira, K. Oyama, H. Yoshida, H. Matsumoto, T. Yamada and H. Okabe : A Study on the Pathogenicity of Bacteria Using A Simulated Root Canal System. J. Endodontics 21, 552-556, 1995.

Tani, Y., M. Tani, T. Yamada and I. Kato : Extracellular antigens of Actinobacillus actinomycetemcomitans Y4 in severe alveolar bone loss patients studied by two-dimensional electrophoresis and Western blots. Microbiol. Immunol. 39, 261-268, 1995.

Honda, M., K. Matsuo, T. Nakasone, Y. Okamoto, H. Yoshizaki, K. Kitamura, W. Sugiura, K. Watanabe, Y. Fukushima, S. Haga, Y. Katsura, H. Tasaka, K. Komuro, T. Yamada, T. Asano, A. Yamazaki and S. Yamazaki : Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guerin vector candidate vaccine for human immunodeficiency virus type 1 in small animals. Proc. Natl. Acad. Sci. USA 92, 10693-10697, 1995.

Matsuo, T., S. Matsumoto, N. Ohara, H. Kitaura, A. Mizuno and T. Yamada : The differential secretion of a unique antigen MPB70 in two major groups of BCG substrains. Microbiol.(GB) 141, 1601-1607, 1995.

Matsumoto, S., T. Matsuo, N. Ohara, H. Hotokezaka, M. Naito, J. Minami and T. Yamada : Cloning and sequencing of a unique antigen MPT70 from M.tuberculosis H37Rv and expression in BCG using E.coli mycobacteria shuttle vector. Scand. J. Immun. 41, 281-287, 1995.

Ohara, N., H. Kitaura, H. Hotokezaka, T. Nishiyama, N. Wada, S. Matsumoto, T. Matsuo M. Naito and T. Yamada : Characterization of the gene encoding the MPB51, one of the major secreted protein antigens of M.bovis BCG and identification of the secreted protein closely related to the fibronectin 85 complex. Scand. J. Immun. 41, 433-442, 1995.

Kitaura, H., N. Ohara, T. Matsuo and T. Yamada : The internal control for the rapid detection of mycobacteria by amplification of a segment of the gene encoding α antigen. Microbiologica(Italy) 18, 429-433, 1995.

 
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