Archives for RIKEN Jun Aruga Laboratory (Lab for Comparative Neurogenesis/Behavioral and Developmental Disorders, 2004-2013)

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Recent Advances

Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses (Kabayama et al., 2013)

SLITRK6 mutations cause myopia and deafness in humans and mice. (Tekin et al., 2013)

Selective control of inhibitory synapse development by Slitrk3-PTPdelta trans-synaptic interaction. (Takahashi et al., 2012)

Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway. (Fujimi et al., 2012)

Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia. (Takashima, Odaka et al., 2011)

Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients. (Hatayama, Ishiguro et al., 2011)

Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice. (Matsumoto et al., 2011)

Discovery of a hallmark sequence motif for inter-zinc finger interaction (Hatayama et al., 2010)

Meningiomas and Zic proteins (Aruga et al., 2010)

Clarification of the role of Slitrk6 in inner ear innervation (Katayama et al., 2009)

Understanding the role of a Tourette syndrome-associated gene (Katayama et al., 2008)

Clarification of the 3D structure of the interspersed nuclear localization signal in zinc finger domain (Hatayama et al., 2008)

Meningeal membranes are required for normal cerebral cortex development (Inoue et al., 2008)

Understanding the evolutionary processes of "tool-kit" genes (Takahashi et al., 2008 and others)


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