教授 伊藤敬
- Endoh, M., Endo, T.A., Endoh, T., Isono, K., Sharif, J., Ohara, O., Toyoda, T., Ito, T.., Eskeland, R., Bickmore, W.A., Vidal, M., Bernstein, B.E., and Koseki, H. (2012). Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity. PLoS Genet 8, e1002774.
- Whitcomb, S.J., Fierz, B., McGinty, R.K., Holt, M., Ito, T., Muir, T.W., and Allis, C.D. (2012). Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Cross-talk with Histone Methyltransferases Dot1L and PRC2. J Biol Chem 287, 23718-23725.
- Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, T., Ma, Y., Chua, K.J., Kubo, Y., Aihara, H., , Ito, T Nagayasu T, Matsuyama T, Hayashi H. (2011). Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel. Cytokine 56, 564-572.
- Katoh Y, Ikura T, Hoshikawa Y, Tashiro S, Ito T, Ohta M, Kera Y, Noda T, Igarashi K. 2011. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein. Mol Cell 41: 554-566.
- Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L. 2010. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature 468: 1124-1128.
- Lancaster OM, Breuer M, Cullen CF, Ito T, Ohkura H. 2010. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila. PLoS Genet 6: e1001179.
- Higashi M, Inoue S, Ito T. 2010. Core histone H2A ubiquitylation and transcriptional regulation. Exp Cell Res 316: 2707-2712. 2009 JCR IF 3.589
- Nakagawa, T., Kajitani, T., Togo, S., Masuko, N., Ohdan, H., Hishikawa, Y., Koji, T., Matsuyama, T., Ikura, T., Muramatsu, M., and Ito, T. 2008. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Genes Dev 22(1): 37-49.
- Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K., and Kamiya, K. 2007. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol 27(20): 7028-7040.
- Brittle, A.L., Nanba, Y., Ito, T., and Ohkura, H. 2007. Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation. Exp Cell Res 313(13): 2780-2785.
- Ito, T. 2007. Role of histone modification in chromatin dynamics. J Biochem (Tokyo) 141(5): 609-614.
- Oki, M., Aihara, H., and Ito, T. (2007). Role of histone phosphorylation in chromatin dynamics and its implications in diseases. Subcell Biochem 41, 319-336.
- Ito, K., Nakajima, Y., Onohara, Y., Takeo, M., Nakashima, K., Matsubara, F., Ito, T., and Yoshimoto, T. 2006. Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition. J Biol Chem 281(44): 33664-33676.
- Jin, C., Kato, K., Chimura, T., Yamasaki, T., Nakade, K., Murata, T., Li, H., Pan, J., Zhao, M., Sun, K., Chiu, R., Ito, T., Nagata, K., Horikoshi, M., and Yokoyama, K.K. 2006. Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nature Structural & Molecular Biology13(4): 331-338.
- Ito, K., Nakajima, Y., Xu, Y., Yamada, N., Onohara, Y., Ito, T., Matsubara, F., Kabashima, T., Nakayama, K., and Yoshimoto, T. 2006. Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis. J Mol Biol 362(2): 228-240.
- Cullen, C.F., A.L. Brittle, T. Ito, and H. Ohkura. 2005. The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. J Cell Biol 171: 593-602.
- Furumatsu, T., M. Tsuda, K. Yoshida, N. Taniguchi, T. Ito, M. Hashimoto, and H. Asahara. 2005. Sox9 and p300 Cooperatively Regulate Chromatin-mediated Transcription. J Biol Chem 280: 35203-8.
- Ivanovska, I., T. Khandan, T. Ito, and T.L. Orr-Weaver. 2005. A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev 19: 2571-82.
- Saeki, H., K. Ohsumi, H. Aihara, T. Ito, S. Hirose, K. Ura, and Y. Kaneda. (2005) Linker histone variants control chromatin dynamics during early embryogenesis. Proc Natl Acad Sci U S A 102: 5697-702.
- Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M. and Ito, T. (2004) Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev, 18, 877-888.
- Furukawa, H., Doh-Ura, K., Okuwaki, R., Shirabe, S., Yamamoto, K., Udono, H., Ito, T., Katamine, S. and Niwa, M. (2004) A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in Urine: CONTAMINATION WITH BACTERIAL OUTER MEMBRANE PROTEINS. J Biol Chem, 279, 23661-23667.
- Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M. and Ito, T. (2004) Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun, 317, 259-264.
- Mori, M., Yoneyama, M., Ito, T., Takahashi, K., Inagaki, F., and Fujita, T. (2004) Identification of ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem 279: 9698-9702.
- Ito, T. 2003. Nucleosome assembly and remodeling. Curr Top Microbiol Immunol
274: 1-22. - Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T.equalcorresponding, and Montminy, M. equalcorresponding(2002) Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol 22: 2974-2983.
- Ura, K., Araki, M., Saeki, H., Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda, Y., and Hanaoka, F. (2001) ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes. Embo J 20: 2004-2014.
- Manning, E.T., Ikehara, T., Ito, T., Kadonaga, J.T., and Kraus, W.L. (2001) p300 Forms a stable, template-committed complex with chromatin: role for the bromodomain. Mol Cell Biol 21: 3876-3887.
- Nakagawa, T., Bulger, M., Muramatsu, M., and Ito, T. (2001) Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor. J Biol Chem 276: 27384-27391.
- Ito, T., Ikehara, T., Nakagawa, T., Kraus, W.L., and Muramatsu, M. (2000) p300-Mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev 14: 1899-1907.
- Ito, T., Levenstein, M.E., Fyodorov, D.V., Kutach, A.K., Kobayashi, R., and Kadonaga, J.T. (1999) ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev 13: 1529-1539.
- Mizuno, T., Nagamura H., Iwamoto, K. S., Ito, T., Fukuhara T., Tokunaga
M.,Tokuoka S., Mabuchi K., and Seyama, T. (1998) RNA from decades-old archival tissue blocks for retrospective studies. Diagnostic Molecular Pathology7:202-208, - Ito, T., Tyler, J.K., and Kadonaga, J.T. (1997) Chromatin assembly factors: a dual function in nucleosome formation and mobilization? Genes Cells 2: 593-600.
- Ito, T., Bulger, M., Pazin, M.J., Kobayashi, R., and Kadonaga, J.T. (1997) ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90: 145-155.
- Ito, T., Tyler, J.K., Bulger, M., Kobayashi, R., and Kadonaga, J.T. (1996) ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem 271: 25041-25048.
- Ito, T., Bulger, M., Kobayashi, R., and Kadonaga, J.T. (1996) Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays. Mol Cell Biol 16: 3112-3124.
- Iwamoto, K. S., Mizuno, T., Ito, T., Tsuyama, N., Kyoizumi, S., and Seyama, T. (1996) Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X irradiation, independently of the cell cycle and cell survival. Cancer Res. 56: 3862-3865.
- Ito,T., Jessica, K. T., Bulger,M., Kobayashi,R., and Kadonaga,J.T. Structure and analysis of a nucleoplasmin-like protein from Drosophila melanogaster. J. Biol. Chem. 271:25041-25048, 1996.
- Iwamoto, K. S., Mizuno, T., Ito, T., Akiyama, M. Takeichi, N., Mabuchi, K., and Seyama, T. Feasibility of using decades-old archival tissues in molecular oncology/epidemiology. American J. Pathology 149: 399-406, 1996.
- Bulger, M., Ito, T., Kamakaka, R.T., and Kadonaga, J.T. 1995. Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein. Proc Natl Acad Sci U S A 92: 11726-11730.
- Ito, T., Seyama.,T., Kyoizumi,S., Teraoka S., Iwamoto K.S., Mizuno T., Tsuyama N., Asahara T., Dohi K., Akiyama M. The usefulness of severe combined immunodeficiency(SCID) mice to study human carcinogenesis. Cancer Letters Vol88: 113 -117, 1995.
- Ito,T., Seyama,T., Iwamoto,K.S., Mizuno T., Tronko N.D., Komissarenko I.V., Cherstovoy E.D., Satow Y., Takeichi N., Dohi K., and Akiyama M. Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident. Lancet Vol344: 259, 1994.
- Ito,T., Seyama,T., Hayashi, Y., Hayashi, T., Dohi, K., Mizuno, T., Iwamoto,K.S., Tsuyama, N., Nakamura, N., Akiyama, M. Establishment of two human thyroid carcinoma cell lines(8305C, 8505C) bearing p53 gene mutations. Int. Journal Oncology 4: 583-586, 1994.
- Ito, T., Seyama, T., Hayashi, T., Mizuno, T., Iwamoto, K. S., Tsuyama, N., Dohi, K., Nakamura, N., Akiyama, M. HaeIII polymorphism in intron 1 of the human p53 gene. Human Genetics Vol93: 222, 1994.
- Ito M., Mishima H., Inai K., Ito T., and Akiyama M. p53 and Rb tumor suppressor gene alterations in retinoblastoma. International Journal Oncology 4:1329-1332, 1994.
- Ito,T., Seyama,T., Iwamoto,K.S., Hayashi, T., Mizuno, T., Tsuyama, N., Dohi, K., Nakamura, N., and Mitoshi, A. In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res. Vol53: 2940-2943, 1993.
- Ito,T., Seyama,T., Mizuno,T., Iwamoto,K.S., Tsuyama, N., Hayashi, Y., Dohi, K., Nakamura, N., and Mitoshi, A. Genetic alterations in thyroid tumor
progression: Association with p53 gene mutations. Jpn. J. Cancer Res. Vol84: 526-531, 1993. - Ito,T., Seyama,T., Mizuno,T., Hayashi, T., Iwamoto,K.S., Dohi, K., Nakamura, N., and Mitoshi, A. Induction of BCR-ABL fusion genes by in vitro X-irradiation. Jpn. J.Cancer Res. Vol84:105-109, 1993.
- Hayashi, T., Seyama, T., Ito, T., Kusunoki, Y., Hirai, Y., Nakamura, N., and Akiyama, M. A simple and rapid method for HLA-DQA1 genotyping by polymerase chain reaction-single strand conformation polymorphism and restriction enzyme cleavage analysis. Electrophoresis, 13: 877-879, 1992.
- Seyama, T., Ito, T., Hayashi, T., Mizuno, T., Nakamura, N., and Akiyama, M. A novel blocker-PCR method for detection of rare mutant alleles in the presence of an excess amount of normal DNA. Nucleic Acids Res., 20: 2493-2496, 1992.
- Ito,T., Seyama,T., Mizuno,T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Nakamura, N., and Mitoshi, A. Unique association of p53 mutations with undifferentiated but not with differentiated carcinoma of the thyroid gland. Cancer Res. Vol52: 1369-1371, 1992.
(文責;長崎大学医学部生化学 教授 伊藤敬)